Correlation between quantitative perfusion histogram parameters of DCE-MRI and PTEN, P-Akt and m-TOR in different pathological types of lung cancer

BMC Medical Imaging

Guangmao Yu¹  Cheng Wang²  Mingyue Zou³  Bingqian Zhang³  Zhenhua Zhao³  Haijia Mao³  Ya’nan Huang³  Minming Zhang⁴ 

[1] Cardiothoracic Surgery, Shaoxing People’s Hospital (Shaoxing Hospital, Zhejiang University School), 312000, Shaoxing, China;Department of Pathology, Shaoxing People’s Hospital (Shaoxing Hospital, Zhejiang University School), 312000, Shaoxing, China;Department of Radiology, Shaoxing People’s Hospital (Shaoxing Hospital, Zhejiang University School), No. 568, North Zhongxing Road, Yuecheng District, 312000, Shaoxing City, Zhejiang Province, China;Department of Radiology, The Second Affiliated Hospital of Zhejiang University, 310009, Hangzhou, China;

关键词: Lung cancer;    Dynamic contrast-enhanced magnetic resonance imaging;    Histogram;    PTEN;    P-Akt;    M-TOR;   

DOI  :  10.1186/s12880-021-00604-5

来源: Springer

【 摘 要 】

BackgroundTo explore if the quantitative perfusion histogram parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) correlates with the expression of PTEN, P-Akt and m-TOR protein in lung cancer.MethodsThirty‐three patients with 33 lesions who had been diagnosed with lung cancer were enrolled in this study. They were divided into three groups: squamous cell carcinoma (SCC, 15 cases), adenocarcinoma (AC, 12 cases) and small cell lung cancer (SCLC, 6 cases). Preoperative imaging (conventional imaging and DCE-MRI) was performed on all patients. The Exchange model was used to measure the phar- macokinetic parameters, including Ktrans, Vp, Kep, Ve and Fp, and then the histogram parameters meanvalue, skewness, kurtosis, uniformity, energy, entropy, quantile of above five parameters were analyzed. The expression of PTEN, P-Akt and m-TOR were assessed by immunohistochemistry. Spearman correlation analysis was used to compare the correlation between the quantitative perfusion histogram parameters and the expression of PTEN, P-Akt and m-TOR in different pathological subtypes of lung cancer.ResultsThe expression of m-TOR (P = 0.013) and P-Akt (P = 0.002) in AC was significantly higher than those in SCC. Vp (uniformity) in SCC group, Ktrans (uniformity), Ve (kurtosis, Q10, Q25) in AC group, Fp (skewness, kurtosis, energy), Ve (Q75, Q90, Q95) in SCLC group was positively correlated with PTEN, and Fp (entropy) in the SCLC group was negatively correlated with PTEN (P < 0.05); Kep (Q5, Q10) in the SCLC group was positively correlated with P-Akt, and Kep (energy) in the SCLC group was negatively correlated with P-Akt (P < 0.05); Kep (Q5) in SCC group and Vp (meanvalue, Q75, Q90, Q95) in SCLC group was positively correlated with m-TOR, and Ve (meanvalue) in SCC group was negatively correlated with m-TOR (P < 0.05).ConclusionsThe quantitative perfusion histogram parameters of DCE-MRI was correlated with the expression of PTEN, P-Akt and m-TOR in different pathological types of lung cancer, which may be used to indirectly evaluate the activation status of PI3K/Akt/mTOR signal pathway gene in lung cancer, and provide important reference for clinical treatment.

【 授权许可】

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