Benign juvenile idiopathic epilepsy in captive Iberian lynx (Lynx pardinus) in the ex situ conservation program (2005–2019)

BMC Veterinary Research

Rodrigo Serra¹  Victoria Asensio²  María J. Perez-Aspa³  Antonio Rivas⁴  Yasmin El Bouyafrouri⁴  José A. Godoy⁵  Jesús Fernández⁶  Juan J. Mínguez⁷  Valentina Lorenzo⁸ 

[1] Centro Nacional de Reprodução de Lince Ibérico, Silves, Portugal;Centro de Cría en cautividad de Lince ibérico (CCLI) de Zarza de Granadilla, Cáceres, Spain;Centro de Cría en cautividad de Lince ibérico (CCLI) la Olivilla. Agencia de Medio Ambiente y Agua de Andalucia, Jaen, Spain;Centro de cría del lince ibérico El Acebuche-OAPN/Tragsatec. Parque Nacional de Doñana, Huelva, Spain;Departamento de Ecología Integrativa, Estación Biológica de Doñana (EBD-CSIC), Sevilla, Spain;Departamento de Mejora Genética Animal, INIA, Madrid, Spain;Hospital Veterinario Guadiamar, Sanlúcar la Mayor, Seville, Spain;Pride Veterinary Centre, Derby, UK;NeurologiaVeterinaria, Getafe, Madrid, Spain;

关键词: Feline;    Wild cat;    Lynx;    Seizure;    Idiopathic epilepsy;    Juvenile epilepsy;    Benign epilepsy;   

DOI  :  10.1186/s12917-021-02868-z

来源: Springer

【 摘 要 】

BackgroundBenign juvenile idiopathic epilepsy has been described in humans but rarely in animals. The objectives of the study were to describe the clinical signs, clinical data, imaging findings, genetic examinations, treatment, long-term outcome and prognosis in Iberian lynx with juvenile epilepsy. Medical records, video recordings and diagnostic data from 2005 to 2019 were reviewed.ResultsTwenty lynx cubs with early onset of epileptic seizures (ES) from the conservation program were included. The average age at seizure onset was 75 days. Isolated and cluster ES were recorded. Focal ES, focal ES evolving into generalized ES with a stereotypical pattern and generalized ES were observed. All the cubs were normal between episodes, had a normal neurological examination and unremarkable investigations. Phenobarbital was used as a first line antiepileptic drug (AED). ES halted 10 days (0–34) after starting treatment in eight out of twenty cubs (40%). Treatment was discontinued in this group after a mean of 578 days and no further ES were reported (mean follow-up longer than 5 years). Eleven animals (55%) continued on AED treatment for a mean of 1306 days (70–3466). An adult-onset was observed for one lynx (5%). Polytherapy was necessary in seven lynxes (35%). The inheritance pattern observed was compatible with an autosomal recessive condition. Based on this assumption, mating between two identified carriers has been avoided since 2012, which may have contributed to the subsequent decrease in prevalence, with no further cases detected in 2018 and 2019.ConclusionsLynx pardinus may have an early onset self-limiting ES syndrome characteristic of benign juvenile idiopathic epilepsy. Information obtained from this study strongly suggests a genetic basis for the here presented epilepsy.

【 授权许可】

CC BY