H2-antagonist in IgE-mediated type I hypersensitivity reactions: what literature says so far?

Clinical and Molecular Allergy

Giuseppe Murdaca¹  Simone Negrini¹  Matteo Borro²  Sharon Chinthrajah³  Andrew Long³ 

[1] Clinical Immunology Unit, Department of Internal Medicine, University of Genoa and Ospedale Policlinico San Martino, 16132, Genoa, Italy;Clinical Immunology Unit, Department of Internal Medicine, University of Genoa and Ospedale Policlinico San Martino, 16132, Genoa, Italy;Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford University, Grant Building, S093, 300 Pasteur Dr., 94305-5101, Stanford, CA, USA;Department of Internal Medicine, San Paolo Hospital, Via Genova 30 -, 17100, Savona, Italy;Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford University, Grant Building, S093, 300 Pasteur Dr., 94305-5101, Stanford, CA, USA;

关键词: H-receptor antagonist;    Histamine;    Type-I hypersensitivity reaction;    Allergy;   

DOI  :  10.1186/s12948-021-00143-y

来源: Springer

【 摘 要 】

Histamine is a monoamine synthesized from the amino acid histidine that is well-known for its role in IgE-mediated anaphylaxis but has shown pleiotropic effects on the immune system, especially in order to promote inflammatory responses. H1-receptor antagonist are common drugs used in mild/moderate allergic reactions whereas H2-receptor antagonist are commonly administered in gastric ulcer but showed some properties in allergy too. The EAACI guidelines for diagnosis and treatment of anaphylactic reactions recommend their use as third-line therapy in adjunct to H1-antagonists. The purpose of this article is to produce a complete summary of findings and evidence known so far about the usefulness of H2-receptor antagonist in allergic reactons.

【 授权许可】

CC BY