Sensitivity to food additives, vaso-active amines and salicylates: a review of the evidence

Clinical and Translational Allergy

C. Venter³  R. Meyer¹  L. Reeves⁴  M. Williams²  Isabel J. Skypala⁵ 

[1] Great Ormond Street NHS Foundation Trust, London, UK;Somerset Partnership NHS Foundation Trust, Somerset, UK;The David Hide Asthma and Allergy Research Centre, Isle of Wight, UK;Oxford Health NHS Foundation Trust, Oxford, UK;Royal Brompton and Harefield NHS Foundation Trust, Sydney Street, London SW3 6NP, UK

关键词: Salicylate;    Histamine;    Allergy;    Additives;    Food;   

Others  :  1230345
DOI  :  10.1186/s13601-015-0078-3

 received in 2015-06-04, accepted in 2015-09-24,  发布年份 2015

【 摘 要 】

Although there is considerable literature pertaining to IgE and non IgE-mediated food allergy, there is a paucity of information on non-immune mediated reactions to foods, other than metabolic disorders such as lactose intolerance. Food additives and naturally occurring ‘food chemicals’ have long been reported as having the potential to provoke symptoms in those who are more sensitive to their effects. Diets low in ‘food chemicals’ gained prominence in the 1970s and 1980s, and their popularity remains, although the evidence of their efficacy is very limited. This review focuses on the available evidence for the role and likely adverse effects of both added and natural ‘food chemicals’ including benzoate, sulphite, monosodium glutamate, vaso-active or biogenic amines and salicylate. Studies assessing the efficacy of the restriction of these substances in the diet have mainly been undertaken in adults, but the paper will also touch on the use of such diets in children. The difficulty of reviewing the available evidence is that few of the studies have been controlled and, for many, considerable time has elapsed since their publication. Meanwhile dietary patterns and habits have changed hugely in the interim, so the conclusions may not be relevant for our current dietary norms. The conclusion of the review is that there may be some benefit in the removal of an additive or a group of foods high in natural food chemicals from the diet for a limited period for certain individuals, providing the diagnostic pathway is followed and the foods are reintroduced back into the diet to assess for the efficacy of removal. However diets involving the removal of multiple additives and food chemicals have the very great potential to lead to nutritional deficiency especially in the paediatric population. Any dietary intervention, whether for the purposes of diagnosis or management of food allergy or food intolerance, should be adapted to the individual’s dietary habits and a suitably trained dietitian should ensure nutritional needs are met. Ultimately a healthy diet should be the aim for all patients presenting in the allergy clinic.

【 授权许可】

   
2015 Skypala et al.

【 参考文献 】

• [1]Muraro A, Werfel T, Hoffmann-Sommergruber K, Roberts G, Beyer K, Bindslev-Jensen C, Cardona V, Dubois A, duToit G, Eigenmann P, Fernandez Rivas M, Halken S, Hickstein L, Høst A, Knol E, Lack G, Marchisotto MJ, Niggemann B, Nwaru BI, Papadopoulos NG, Poulsen LK, Santos AF, Skypala I, Schoepfer A, Van Ree R, Venter C, Worm M, Vlieg-Boerstra B, Panesar S, de Silva D, Soares-Weiser K, Sheikh A, Ballmer-Weber BK, Nilsson C, de Jong NW, Akdis CA, EAACI Food Allergy and Anaphylaxis Guidelines Group. EAACI food allergy and anaphylaxis guidelines: diagnosis and management of food allergy. Allergy. 2014, 69:1008–25.
• [2]Kang MG, Song WJ, Park HK, Lim KH, Kim SJ, Lee SY, et al.: Basophil activation test with food additives in chronic urticaria patients. Clin Nutr Res 2014, 3:9-16.
• [3]Werfel T: Skin manifestations in food allergy. Allergy 2001, 56(Suppl 67):98-101.
• [4]Cardinale F, Mangini F, Berardi M, Sterpeta LM, Chinellato I, Dellino A Cristofori F, Di Domenico F, Mastrototaro MF, Cappiello A, Centoducati T, Carella F, Armenio L. Intolerance to food additives: an update. Minerva Pediatr. 2008;60:1401–09.
• [5]Vally H, Misso NL: Adverse reactions to the sulphite additives. Gastroenterol Hepatol Bed Bench 2012, 5:16-23.
• [6]Maintz L, Novak N: Histamine and histamine intolerance. Am J Clin Nutr 2007, 85:1185-11896.
• [7]Azuma K, Uchiyama I, Katoh T, Ogata H, Arashidani K, Kunugita N: Prevalence and characteristics of chemical intolerance: a Japanese population-based study. Arch Environ Occup Health 2014.
• [8]Schroeter LC. Sulfur dioxide: applications in foods, beverages and pharmaceuticals. New York: Pergamon Press; 1966.
• [9]Karovicova J, Simko P. Preservatives in food. In: Nollet LML, editor. Handbook of food analysis. New York; 1996. p. 1745–47.
• [10]Yang WH, Purchase EC: Adverse reactions to sulfites. CMAJ 1985, 133:865-867.
• [11]Verger P, Chambolle M, Babayou P, Le Breton S, Volatier JL: Estimation of the distribution of the maximum theoretical intake for ten additives in France. Food Addit Contam 1998, 15:756-759.
• [12]Zhang JB, Zhang H, Wang HL, Zhang JY, Luo PJ, Zhu L, Wang ZT: Risk analysis of sulfites used as food additives in China. Biomed Environ Sci 2014, 27:147-154.
• [13]Directive 2003/89/EC of the European Parliament and of the Council of 10 November 2003. Amending directive 2000/13/EC as regards indication of the ingredients present in foodstuffs. OJ L 2003;308:15–8.
• [14]Food and Drug Administration: New sulfite regulations FDA Drug Bull 1986, 16:17-18.
• [15]Manzi P, Masci V, Quattrucci E. Valutazione dell’ingestione potenziale media de alcuni conservanti basata sulla dieta italana di riferimento. In: Consiglio Nazionale delle Ricerche. Agrobiotecnologie nei processi di valorizzazione dei prodotti e sottoprodotti agricoli. Progetto R.A.I.S.A. (Riecerche Avanzante per Innovazioni nei Sisterna Agricolo), Sottoprogetto 4. (Roma: CNR) 1992;II:1093–96.
• [16]Martin LB, Nordlee JA, Taylor SL: Sulfite residues in restaurant salads. J Food Prot 1986, 49:126-129.
• [17]Simon RA: Update on sulfite sensitivity. Allergy 1998, 53:72-74.
• [18]Bush RK, Taylor SL, Holden K, Nordlee JA, Busse WW: The prevalence of sensitivity to sulfiting agents in asthmatics. Am J Med 1986, 81:816-820.
• [19]Buckley CE III, Saltzman HA, Seiker HO: The prevalence and degree of sensitivity to ingested sulfites. J Allergy Clin Immunol 1985, 75:144.
• [20]Ban GY, Kim MA, Yoo HS, Ye YM, Park HS. Letter to the editor. Two major phenotypes of sulfite hypersensitivity: asthma and urticaria. Yonsei Med J. 2014;55:542–4.
• [21]Asero R: Multiple intolerance to food additives. J Allergy Clin Immunol 2002, 110:531-532.
• [22]Simon R: Adverse reactions to food and drug additives. Immunol Allergy Clin N Am 1996, 16:137-176.
• [23]Yang W, Purchase E, Rivington R: Positive skin tests and Prausnitz–Kustner reactions in metabisulfite-sensitive subjects. J Allergy Clin Immunol. 1986, 78:443.
• [24]Boxer M, Bush R, Harris K, Patterson R, Pruzansky J, Yang W: The laboratory evaluation of IgE antibody to metabisulfites in patients skin test positive to metabisulfites. J Allergy Clin Immunol. 1988, 82:622-626.
• [25]Prenner B, Stevens J: Anaphylaxis after ingestion of sodium bisulfite. Ann Allergy 1976, 37:180.
• [26]Gong H Jr, Linn WS, Terrell SL, Anderson KR, Clark KW: Anti-inflammatory and lung function effects of montelukast in asthmatic volunteers exposed to sulphur dioxide. Chest 2001, 119:402-408.
• [27]Howland WA, Simon RA: Restaurant-provoked asthma: sulfite sensitivity? J Allergy Clin Immunol 1985, 75:145.
• [28]Taylor SL, Bush RK, Selner JC, et al.: Sensitivity to sulfited foods among sulfite-sensitive subjects with asthma. J Allergy Clin Immunol 1988, 81:1159-1167.
• [29]Vally H, Thompson PJ: Role of sulfite additives in wine induced asthma: single dose and cumulative dose studies. Thorax 2001, 56:763-769.
• [30]Sieber R, Butikofer U, Bosset JO, Ruegg M: Benzoic acid as a natural component of foods—a review. Mitt Lebensmittelunters Hyg 1989, 80:345-362.
• [31]Wibbertmann A, Kielhorn J, Koennecker G, Mangelsdorf I, Melber C. Concise International Chemical Assessment Document 26. Benzoic acid and sodium benzoate. Vol. 26. Geneva: World Health Organisation; 2000. p. 1–48.
• [32]Rangan C, Barceloux DG: Food additives and sensitivities. Dis Mon 2009, 55:292-311.
• [33]Khasnavis S, Pahan K: Sodium benzoate, a metabolite of cinnamon and a food additive, upregulates neuroprotective Parkinson disease protein DJ-1 in astrocytes and neurons. J Neuroimmune Pharmacol. 2012, 7:424-435.
• [34]European Parliament and Council Directive. European Parliament and Council Directive No 95⁄2⁄EC of 20 February 1995 on food additives other than colours and sweeteners. Off J Eur Union 1995;L61⁄18:1.
• [35]The European Parliament and the Council of the European Union. Directive 2003⁄15⁄EC of the European Parliament and of the Council of 27 February 2003, amending Council Directive 76⁄768⁄EEC on the approximation of the laws of the member.
• [36]Wuthrich B: Food-induced cutaneous adverse reactions. Allergy 1998, 53:131-135.
• [37]Van Bever HP, Docx M, Stevens WJ: Food and food additives in severe atopic dermatitis. Allergy 1989, 44:588-594.
• [38]Worm MEI, Sterry W, Zuverbier T: Clinical relevance of food additives in adult patients with atopic dermatitis. Clin Exp Allergy 2000, 30:407-414.
• [39]Park HW, Park CH, Park SH, Park JY, Park HS, Yang HJ, et al.: Dermatologic adverse reactions to 7 common food additives in patients with allergic diseases: a double-blind, placebo-controlled study. J Allergy Clin Immunol. 2008, 121:1059-1061.
• [40]Weber RWHM, Raine D: Incidence of bronchoconstriction due to aspirin, azo dyes, non-azo dyes, and preservatives in a population of perennial asthmatics. J Allergy Clin Immunol. 1979, 64:32-37.
• [41]Tarlo SMBI: Tartrazine and benzoate challenge and dietary avoidance in chronic asthma. Clin Allergy. 1982, 12:303-312.
• [42]Pacor MLDLG, Martinelli N, Mansueto P, Rini GB, Corrocher R: Monosodium benzoate hypersensitivity in subjects with persistent rhinitis. Allergy 2004, 59:192-197.
• [43]Ortolani CPE, Luraghi MT, Della-Torre F, Bellani M, Zanussi C: Diagnosis of food intolerance to food additives. Ann Allergy. 1984, 53:587-591.
• [44]Simon RA: Additive-induced urticaria: experience with monosodium glutamate (MSG). J Nutr 2000, 130:1063S-1066S.
• [45]Ros AJL, Michaelsson G: A follow-up study of patients with recurrent urticaria and hypersensitivity to aspirin, benzoates and azo dyes. Br J Dermatol 1976, 95:19-24.
• [46]Ehlers INB, Binder C, Zuberbier T: Role of nonallergic hypersensitivity reactions in children with chronic urticaria. Allergy 1998, 53:1074-1077.
• [47]Gibson A, Clancy R: Management of chronic idiopathic urticaria by the identification and exclusion of dietary factors. Clin Allergy. 1980, 10:699-704.
• [48]Rajan JP, Simon RA, Bosso JV: Prevalence of sensitivity to food and drug additives in patients with chronic idiopathic urticaria. J Allergy Clin Immunol Pract. 2014, 2:168-171.
• [49]Yamaguchi S, Ninomiya K: Umami and food palatability. J Nutr 2000, 130:921S-926S.
• [50]Metcalfe DD Sampson H, Simon RA, Lack G. Food allergy: adverse reaction to foods and food additives. 5th ed. New York: Wiley-Blackwell; 2014.
• [51]Kwok R: Chinese restaurant syndrome. New Eng J Med. 1968, 278:796.
• [52]Kenney RA: Placebo-controlled studies of human reaction to oral monosodium l-glutamate. Adv Biochem Physiol, Glutamic Acid; 1979.
• [53]Morselli PLGS: Monosodium glutamate and the Chinese Restaurant Syndrome. Nature 1970, 227:611-612.
• [54]Geha RS, Beiser A, Ren C, Patterson R, Greenberger PA, Grammer LC, Ditto AM, Harris KE, Shaughnessy MA, Yarnold PR, Corren J, Saxon A: Multicenter, double-blind, placebo-controlled, multiple-challenge evaluation of reported reactions to monosodium glutamate. J Allergy Clin Immunol. 2000, 106:973-980.
• [55]http://www.fda.gov/. Accessed 1 July 2015.
• [56]Wilson BGBS: Adverse reactions to food additives. Ann Allergy Asthma Immunol 2005, 95:499-507.
• [57]Gultekin F, Doguc DK: Allergic and immunologic reactions to food additives. Clin Rev Allergy Immunol 2013, 45:6-29.
• [58]Allen DHDJ, Baker G: Monosodium L-glutamate-induced asthma. J Allergy Clin Immunol. 1987, 80:530-537.
• [59]Schwartzstein RMKM, Weinberger SE, Weiss JW, Drazen JM: Airway effects of monosodium glutamate in subjects with chronic stable asthma. J Asthma 1987, 24:167-172.
• [60]Woods RKWJ, Thien F, Abramson M, Walters EH: The effects of monosodium glutamate in adults with asthma who perceive themselves to be monosodium glutamate-intolerant. J Allergy Clin Immunol. 1998, 101:762-771.
• [61]Germano PCS, Hahn B, Metcalfe DD: An evaluation of clinical reactions to monosodium glutamate (MSG) in asthmatics, using blinded placebo-controlled challenge. J Allergy Clin Immunol. 1991, 87:177.
• [62]Asero RBG: Chronic rhinitis with nasal polyposis associated with sodium glutamate intolerance. Int Arch Allergy Immunol 2007, 144:159-161.
• [63]Gray D: Food and Drug Administration Memorandum, glutamate in food. Fed Regist. 1996, 61:48102-48110.
• [64]Yang WHDM, Herbert M, Mao Y, Karsh J: The monosodium glutamate symptom complex: assessment in a double-blind, placebo-controlled, randomised study. J Allergy Clin Immunol. 1997, 99:757-762.
• [65]Baad-Hansen L, Cairns B, Ernberg M, Svensson P: Effect of systemic monosodium glutamate (MSG) on headache and pericranial muscle sensitivity. Cephalalgia 2010, 30:68-76.
• [66]Jansen SC, van Dusseldorp M, Bottema KC, Dubois AE: Intolerance to dietary biogenic amines: a review. Ann Allergy Asthma Immunol 2003, 91:233-240.
• [67]Fogel WA, Lewinski A, Jochem J: Histamine in food: is there anything to worry about? Biochem Soc Trans 2007, 35:349-352.
• [68]Bodmer S, Imark C, Kneubühl M: Biogenic amines in foods: histamine and food processing. Inflamm Res 1999, 48:296-300.
• [69]Skypala I: Other causes of food hypersensitivity. In Food hypersensitivity: diagnosing and managing food allergies and intolerance. Edited by Skypala I, Venter C. Wiley-Blackwell, West Sussex; 2009:p210-p240.
• [70]Attaran RR, Probst F: Histamine fish poisoning: a common but frequently misdiagnosed condition. Emerg Med J 2000, 19:474-475.
• [71]Wöhrl S, Hemmer W, Focke M, Rappersberger K, Jarisch R: Histamine intolerance-like symptoms in healthy volunteers after oral provocation with liquid histamine. Allergy Asthma Proc 2004, 25:305-311.
• [72]Vickerstaff Joneja J, Carmona-Silva C. Outcome of a histamine-restricted diet based on chart audit. J Nutr Environ Med. 2001;11:249–62.
• [73]Yang J, Ding X, Qin Y, Zeng Y: Safety assessment of the biogenic amines in fermented soya beans and fermented bean curd. J Agric Food Chem 2014, 62:7947-7954.
• [74]Kanny G, Gerbaux V, Olszewski A, Frémont S, Empereur F, Nabet F, Kanny G, Gerbaux V, Olszewski A, Frémont S, Empereur F, Nabet F, Cabanis JC, Moneret-Vautrin DA: No correlation between wine intolerance and histamine content of wine. J Allergy Clin Immunol 2001, 107:375-378.
• [75]Vlieg-Boerstra BJ, van der Heide S, Oude Elberink JN, Kluin-Nelemans JC, Dubois AE. Mastocytosis and adverse reactions to biogenic amines and histamine-releasing foods: what is the evidence? Neth J Med. 2005;63:244–9.
• [76]Wantke F, Götz M, Jarisch R: Histamine-free diet: treatment of choice for histamine-induced food intolerance and supporting treatment for chronic headaches. Clin Exp Allergy 1993, 23:982-985.
• [77]King W, McCargar L, Joneja JM, Barr SI: Benefits of a histamine-reducing diet for some patients with chronic urticaria and angioedema. Can J Diet Pract Res 2000, 61:24-26.
• [78]Böhn L, Störsrud S, Törnblom H, Bengtsson U, Simrén M: Self-reported food-related gastrointestinal symptoms in IBS are common and associated with more severe symptoms and reduced quality of life. Am J Gastroenterol 2013, 108:634-641.
• [79]Lessof MH, Gant V, Hinuma K, Murphy GM, Dowling RH: Recurrent urticaria and reduced diamine oxidase activity. Clin Exp Allergy 1990, 20:373-376.
• [80]Cho HJ, Cho SI, Kim HO, Park CW, Lee CH: Lack of association of plasma histamine with diamine oxidase in chronic idiopathic urticaria. Ann Dermatol 2013, 25:189-195.
• [81]Kofler L, Ulmer H, Kofler H. Histamine 50-skin-prick test: a tool to diagnose histamine intolerance. ISRN Allergy 2011:353045.
• [82]Raithel M, Baenkler HW, Naegel A, Buchwald F, Schultis HW, Backhaus B, Kimpel S, Koch H, Mach K, Hahn EG, Konturek PC: Significance of salicylate intolerance in diseases of the lower gastrointestinal tract. J Physiol Pharmacol 2005, 56:89-102.
• [83]Amann R, Peskar BA: Anti-inflammatory effects of aspirin and sodium salicylate. Eur J Pharmacol 2002, 447:1-9.
• [84]Hare LG, Woodside JV, Young IS: Dietary salicylates. J Clin Pathol 2003, 56:649-650.
• [85]Paterson JR, Srivastava R, Baxter GJ, Graham AB, Lawrence JR: Salicylic acid content of spices and its implications. J Agric Food Chem 2006, 54:2891-2896.
• [86]Duthie GG, Wood AD: Natural salicylates: foods, functions and disease prevention. Food Funct. 2011, 2:515-520.
• [87]Swain AR, Dutton SP, Truswell AS: Salicylates in foods. J Am Diet Assoc 1985, 85:950-960.
• [88]Venema DP, Hollman PCH, Janssen KPLTM, Katan MB. Determination of acetylsalicylic acid and salicylic acid in foods, using HPLC with fluorescence detection. J Agric Food Chem. 1996;44:1762–7.
• [89]Scotter MJ, Roberts DPT, Wilson LA, Howard FAC, Davis J, Mansell N: Free salicylic acid and acetyl salicylic acid content of foods using gas chromatography-mass spectrometry. Food Chem 2007, 105:273-279.
• [90]Wood A, Baxter G, Thies F, Kyle J, Duthie G: A systematic review of salicylates in foods: estimated daily intake of a Scottish population. Mol Nutr Food Res 2011, 55:S7-S14.
• [91]Janssen KTLPM, Hollman PCH, Venema DP, van Staveren WA and Katan MB. Salicylates in foods. Nut Rev. 1996;54:357–9.
• [92]Baxter GJ, Graham AB, Lawrence JR, Wiles D, Paterson JR: Salicylic acid in soups prepared from organically and non-organically grown vegetables. Eur J Nutr 2001, 40:289-292.
• [93]Heiska S, Rousi M, Turtola S, Meier B, Tirkkonen V, Julkunen-Titto R: The effect of genotype and cultivation method on the total salicylate yield of dark leaved willows. Plant Med 2005, 71:1134-1139.
• [94]Janssen KTLPM, Hollman PCH, Reichmann E, Venema DP, van Staveren WA and Katan MB. Urinary salicylate excretion in subjects eating a variety of diets shows the amounts of bioavailable salicylates in foods are low. Am J Clin Nutr. 1996;64:743–7.
• [95]Lawrence JR, Peter R, Baxter G, Robson J, Graham AB, Paterson JR: Urinary excretion of salicyluric and salicylic acids by non-vegetarians, vegetarians and patients taking low-dose aspirin. J Clin Pathol 2003, 56:651-653.
• [96]Baenkler H-W: Salicylate intolerance. Dtsch Arztebl Int. 2008, 105:137-142.
• [97]Mitchell JE, Skypala I: Aspirin and salicylate in respiratory disease. Rhinology. 2013, 51:195-205.
• [98]Picado C, Fernandez-Morata JC, Juan M, Roca-Ferrer J, Fuentes M, Xaubet A, Mullol J: Cyclooxygenase-2 mRNA is down expressed in nasal polyps from aspirin-sensitive asthmatics. Am J Resp Crit Care Med 1999, 160:291-296.
• [99]Corder EH, Buckley CE: Aspirin, salicylate, sulfite and tartrazine-induced broncho-constriction. Safe doses and case definition in epidemiological studies. J Clin Epidemiol 1995, 48:1269-1275.
• [100]Dahlén B, Boréus LO, Anderson P, Andersson R, Zetterström O: Plasma acetylsalicylic acid and salicylic acid levels during aspirin provocation in aspirin-sensitive subjects. Allergy 1994, 49:43-49.
• [101]Gibson PR: Food intolerance in functional bowel disorders. J Gastroenterol Hepatol 2011, 26:128-131.
• [102]Barrett JS, Gibson PR: Fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) and nonallergic food intolerance: FODMAPs or food chemicals? Ther Adv Gastroenterol. 2012, 5:261-268.
• [103]Supramaniam GWJ: Artificial food additive intolerance in patients with angio-oedema and urticaria. Lancet 1986, 2:907-909.
• [104]Paul SP, Barnard P, Soondrum K, Candy DC: Antimigraine (low-amine) diet may be helpful in children with cyclic vomiting syndrome. J Pediatr Gastroenterol Nutr 2012, 54:698-699.
• [105]McCann D, Barrett A, Cooper A, Crumpler D, Dalen L, Grimshaw K, Kitchin E, Lok K, Porteous L, Prince E, Sonuga-Barke E, Warner JO, Stevenson J: Food additives and hyperactive behaviour in 3-year-old and 8/9-year-old children in the community: a randomised, double-blinded, placebo-controlled trial. Lancet 2007, 370:1560-1567.
• [106]Food Standards Agency. Final technical report for additives and behaviour study submitted by School of Psychology, University of Southampton, 2007.
• [107]Sanz J, Martorell A, Torro I, Carlos CJ, Alvarez V: Intolerance to sodium metabisulfite in children with steroid-dependent asthma. J Investig Allergol Clin Immunol 1992, 2:36-38.
• [108]Anibarro B, Caballero T, Garcia-Ara C, Diaz-Pena JM, Ojeda JA: Asthma with sulfite intolerance in children: a blocking study with cyanocobalamin. J Allergy Clin. Immunol 1992, 90:103-109.
• [109]Hoffmann KM, Gruber E, Deutschmann A, Jahnel J, Hauer AC: Histamine intolerance in children with chronic abdominal pain. Arch Dis Child 2013, 98:832-833.
• [110]Rosell-Camps A, Zibetti S, Pérez-Esteban G, Vila-Vidal M, Ferrés-Ramis L, García-Teresa-García E: Histamine intolerance as a cause of chronic digestive complaints in pediatric patients. Rev Esp Enferm Dig 2013, 105:201-206.
• [111]Loblay RH, Soutter VL, Swain AR: Salicylate elimination diets in children. MJA 2013, 198:603.
• [112]Gray PE, Mehr S, Katelaris CH, Wainstein BK, Star A, Campbell D, Joshi P, Wong M, Frankum B, Keat K, Dunne G, Dennison B, Kakakios A, Ziegler JB: Salicylate elimination diets in children: is food restriction supported by the evidence? MJA 2013, 198:600-602.
• [113]Barker DJP: Introduction: the window of opportunity. J Nutr 2007, 137:1058-1059.
• [114]Holland D, Chang L, Ernst TM, Curran M, Buchthal SD, Alicata D, Skranes J, Johansen H, Hernandez A, Yamakawa R, Kuperman JM, Dale AM: Structural growth trajectories and rates of change in the first 3 months of infant brain development. JAMA Neurol. 2014, 71:1266-1274.
• [115]Ventura AK, Worobey J: Early influences on the development of food preferences. Curr Biol 2013, 23:R40140-R40148.
• [116]Kim J, Kwon J, Noh G, Lee SS: The effects of elimination diet on nutritional status in subjects with atopic dermatitis. Nutr Res Pract. 2013, 7:488-494.
• [117]Skypala I, Vlieg-Boerstra B: Food intolerance and allergy: increased incidence or contemporary inadequate diets? Curr Opin Clin Nutr Metab Care. 2014, 17:442-447.
• [118]Leclercq C, Molinaro MG, Piccinelli R, Baldini M, Arcella D, Stacchini P: Dietary intake exposure to sulphites in Italy—analytical determination of sulphite-containing foods and their combination into standard meals for adults and children. Food Addit Contam 2000, 17:979-989.
• [119]Heimhuber B, Herrmann K: Benzoe-, Phylessig-, 3-Phenylpropan- und Zimts- aure sowie benzoglucosen in einigen Obst-und Fruchtgemusearten. Dtsch Le- bensmitt Rundsch 1990, 86:205-209.
• [120]Campbell HE, Escudier MP, Patel P, Challacombe SJ, Sanderson JD, Lomer MC: Review article: cinnamon- and benzoate-free diet as a primary treatment for orofacial granulomatosis. Aliment Pharmacol Ther 2011, 34:687-701.
• [121]Williams AN, Woessner KM: Monosodium glutamate ‘allergy’: menace or myth? Clin Exp Allergy 2009, 39:640-646.
• [122]Visciano P, Schirone M, Tofalo R, Suzzi G: Biogenic amines in raw and processed seafood. Front Microbiol. 2012, 3:188.
• [123]Linares DM, del Rio B, Ladero V, Martinez N, Fernandez M, Cruz Martin and Alverez MA. Factors influencing biogenic amines accumulation in dairy products. Front Microbiol. 2012;3:180.
• [124]Chung BY, Cho SI, Ahn IS, Lee HB, Kim HO, Park CW, Lee CH: Treatment of atopic dermatitis with a low histamine diet. Ann Dermatol 2011, 23(Supp 1):S91-S95.
• [125]Shukla S, Kim J-K, Kim M. Occurrence of biogenic amines in soybean food products, soybean and health, Prof. Hany El-Shemy (Ed.), ISBN: 978-953-307-535-8, InTech; 2011. doi:10.5772/19021.
• [126]Halász A, Baráth A, Simon-Sarkadi L, Holzapfe W: Biogenic amines and their production by microorganisms in food. Trends Food Sci Technol 1994, 5(2):42-49.