Rapid systemic surge of IL-33 after severe human trauma: a prospective observational study

Molecular Medicine

Torsten Eken¹  William Ottestad¹  Camilla Schjalm²  Tom Eirik Mollnes³  Lars la Cour Poulsen⁴  Guttorm Haraldsen⁴  Peter Lundbäck⁴  Olav Sundnes⁵ 

[1] Department of Anaesthesiology, Division of Emergencies and Critical Care, Oslo University Hospital Ullevål, Oslo, Norway;Division of Critical Care, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway;K.G Jebsen Inflammation Research Centre, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway;Department of Immunology, Oslo University Hospital, Oslo, Norway;K.G Jebsen Inflammation Research Centre, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway;Department of Immunology, Oslo University Hospital, Oslo, Norway;Reserach Laboratory, Nordland Hospital, Bodø, and K.G.Jebsen TREC, University of Tromsø, Tromsø, Norway;Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, Trondheim, Norway;K.G Jebsen Inflammation Research Centre, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway;Department of Pathology, Oslo University Hospital, Rikshospitalet, N-0027, Oslo, Norway;K.G Jebsen Inflammation Research Centre, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway;Department of Pathology, Oslo University Hospital, Rikshospitalet, N-0027, Oslo, Norway;Department of Dermatology, Oslo University Hospital, Oslo, Norway;

关键词: Alarmins;    Interleukin-33;    Biomarkers;    Immunity;    Innate;    Wounds and Injuries;    Kinetics;    Humans;    Critical Care;    Prospective Studies;   

DOI  :  10.1186/s10020-021-00288-1

来源: Springer

【 摘 要 】

BackgroundAlarmins are considered proximal mediators of the immune response after tissue injury. Understanding their biology could pave the way for development of new therapeutic targets and biomarkers in human disease, including multiple trauma. In this study we explored high-resolution concentration kinetics of the alarmin interleukin-33 (IL-33) early after human trauma.MethodsPlasma samples were serially collected from 136 trauma patients immediately after hospital admission, 2, 4, 6, and 8 h thereafter, and every morning in the ICU. Levels of IL-33 and its decoy receptor sST2 were measured by immunoassays.ResultsWe observed a rapid and transient surge of IL-33 in a subset of critically injured patients. These patients had more widespread tissue injuries and a greater degree of early coagulopathy. IL-33 half-life (t1/2) was 1.4 h (95% CI 1.2–1.6). sST2 displayed a distinctly different pattern with low initial levels but massive increase at later time points.ConclusionsWe describe for the first time early high-resolution IL-33 concentration kinetics in individual patients after trauma and correlate systemic IL-33 release to clinical data. These findings provide insight into a potentially important axis of danger signaling in humans.

【 授权许可】

CC BY