Tetrahedral Framework Nucleic Acid-Based Delivery of Resveratrol Alleviates Insulin Resistance: From Innate to Adaptive Immunity

Nano-Micro Letters

Shuanglin Peng¹  Yanjing Li²  Yang Gao²  Dexuan Xiao²  Sirong Shi²  Shaojingya Gao²  Yunfeng Lin³  Ying Zhu⁴ 

[1] Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Southwest Medical University, 646000, Luzhou, P. R. China;State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, P. R. China;State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, 610041, Chengdu, P. R. China;College of Biomedical Engineering, Sichuan University, 610041, Chengdu, P. R. China;Zhangjiang Laboratory, Shanghai Advanced Research Institute, Chinese Academy of Sciences, 201210, Shanghai, P. R. China;CAS Key Laboratory of Interfacial Physics and Technology, Division of Physical Biology, Shanghai Institute of Applied Physics, Shanghai Synchrotron Radiation Facility, Chinese Academy of Sciences, 201800, Shanghai, P. R. China;

关键词: Tetrahedral framework nucleic acid;    Resveratrol;    Insulin resistance;    Inflammation;    Innate immunity;    Adaptive immunity;   

DOI  :  10.1007/s40820-021-00614-6

来源: Springer

【 摘 要 】

tsTetrahedral framework nucleic acid (tFNA)-based delivery of resveratrol (RSV) ameliorates the performance of RSV.tFNAs-RSV improve insulin sensitivity in high-fat diet-fed mice by promoting Treg and Th2 and suppressing Th1 and Th17, and switching macrophage from M1 to M2 phenotype both in vitro and in vivo.

【 授权许可】

CC BY