Resveratrol reduces chronic inflammation and improves insulin action in the myocardium of high-fat diet-induced obeserats

Revista de Nutrição

Thaís Fernandes Luciano¹  Schérolin De Oliveira Marques¹  Bruno Luiz Da Silva Pieri¹  Daniela Roxo De Souza¹  Fabio Santos De Lira¹  Cláudio Teodoro De Souza¹ 

关键词: Obesity;    Resveratrol;    Insulin resistance;    Inflammation;    Obesidade;    Resveratrol;    Resistência à insulina;    Inflamação;   

DOI  :  10.1590/1415-52732014000200002

来源: SciELO

【 摘 要 】

OBJECTIVE:To evaluate the effects of resveratrol on insulin signaling and inflammation pathway in the myocardium of high-fat diet-induced obese rats.METHODS:Thirty Wistar rats were divided into a control group (n=10, standard diet), obese group (n=10, high-fat diet), and obese supplemented with resveratrol group (n=10, 20 mg/kg/day) for eight weeks. An insulin tolerance test was performed at the end of the study period "0" (without insulin), 5, 10, 15, 20, 25, and 30 minutes after an intraperitoneal injection of insulin (2 U/kg). Body and epididymal adipose tissue were weighed. Fragments of the myocardium were extracted for Western blot analyses of insulin pathway and proinflammatory molecules.RESULTS:Resveratrol increased the rate of glucose disappearance, phosphorylation of the insulin receptor, insulin receptor substrate 1, and protein kinase B; and reduced expression of tumor necrosis factor alpha and of the molecules involved in proinflammatory signal transduction, namely Ikappa B kinase and nuclear factor kappa B complex. The results also suggest that higher insulin sensitivity and lower levels of proinflammatory molecules occurred regardless of weight and epididymal adipose tissue loss.CONCLUSION:Resveratrol increases insulin action and reduces inflammatory molecules in the myocardium.

【 授权许可】

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