Structures, Chemical Conversions, and Cytotoxicity of Tricholopardins C and D, Two Tricholoma Triterpenoids from the Wild Mushroom Tricholoma pardinum

Natural Products and Bioprospecting

Juan He¹  Ji-Kai Liu¹  Tao Feng¹  Zheng-Hui Li¹  Chen Shi¹  Yue-Ling Peng² 

[1] School of Pharmaceutical Sciences, South-Central University for Nationalities, 430074, Wuhan, People’s Republic of China;The Third People’s Hospital of Datong, 037000, Datong, People’s Republic of China;

关键词: Tricholoma pardinum;    Tricholoma;    Chemical conversion;    Cytotoxicity;   

DOI  :  10.1007/s13659-021-00297-x

来源: Springer

【 摘 要 】

Two undescribed Tricholoma triterpenoids, namely tricholopardins C (1) and D (2), were isolated from the wild mushroom Tricholoma pardinum. Their structures with absolute configurations were elucidated by spectroscopic methods, as well as the single crystal X-ray diffraction. Compounds 1 and 2 were further obtained by chemical conversions from the known analogues. Compound 1 showed significant cytotoxicity to MCF-7 and Hela cell lines with IC50 values of 4.7 μM and 9.7 μM, respectively. Its mechanism of inducing MCF-7 cell apoptosis was studied briefly.Graphical Abstract

【 授权许可】

CC BY