Modes of transmission and attack rates of group A Streptococcal infection: a protocol for a systematic review and meta-analysis

Systematic Reviews

Mark E. Engel¹  Jessica Daw²  Janessa Pickering²  Dylan D. Barth³  Tracy McRae³  Ruomei Xu³  Stephanie Enkel³  Jonathan Carapetis⁴  Asha C. Bowen⁴  Rosemary Wyber⁵ 

[1] AFROStrep Registry, Department of Medicine, The University of Cape Town, Cape Town, South Africa;Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, Perth, Western Australia, Australia;Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, Perth, Western Australia, Australia;The University of Western Australia, Perth, Western Australia, Australia;Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, Perth, Western Australia, Australia;The University of Western Australia, Perth, Western Australia, Australia;Department of Infectious Diseases, Perth Children’s Hospital, Perth, Western Australia;Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, Perth, Western Australia, Australia;The University of Western Australia, Perth, Western Australia, Australia;The George Institute for Global Health, Sydney, New South Wales, Australia;

关键词: Streptococcus;    Transmission;    Systematic review;    Environmental health;    Public health;   

DOI  :  10.1186/s13643-021-01641-5

来源: Springer

【 摘 要 】

BackgroundGroup A Streptococcus (Strep A) is an important cause of mortality and morbidity globally. This bacterium is responsible for a range of different infections and post-infectious sequelae. Summarising the current knowledge of Strep A transmission to humans will address gaps in the evidence and inform prevention and control strategies. The objective of this study is to evaluate the modes of transmission and attack rates of group A streptococcal infection in human populations.MethodsThis systematic review protocol was prepared according to the Preferred Reporting Items for Systematic reviews and Meta-analysis Protocols (PRISMA-P) 2015 Statement. Using a comprehensive search strategy to identify any transmission studies that have been published in English since 1980, full-text articles will be identified and considered for inclusion against predefined criteria. We will include all studies reporting on Strep A transmission, who have identified a mode of transmission, and who reported attack rates. Risk of bias will be appraised using an appropriate tool. Our results will be described narratively and where feasible and appropriate, a meta-analysis utilizing the random-effects model will be used to aggregate the incidence proportions (attack rates) for each mode of transmission. In addition, we will also evaluate the emm genotype variants of the M protein causing Strep A infection and the association with transmission routes and attack rates, if any, by setting, socioeconomic background and geographical regions.DiscussionWe anticipate that this review will contribute to elucidating Strep A modes of transmission which in turn, will serve to inform evidence-based strategies including environmental health activities to reduce the transmission of Strep A in populations at risk of severe disease.Trial registrationSystematic review registration: PROSPERO (CRD42019138472).

【 授权许可】

CC BY