Screening is associated with lower mastectomy rates in eastern Switzerland beyond stage effects

BMC Cancer

Rudolf Morant¹  Esther Walser²  Christian Herrmann²  Mohsen Mousavi²  Beat Thürlimann³ 

[1]Cancer League of Eastern Switzerland, St. Gallen, Switzerland

[2]Cancer Registry of Eastern Switzerland, Cancer League of Eastern Switzerland, St. Gallen, Switzerland

[3]Division Oncology-Haematology, Department of Internal Medicine, St. Gallen, Switzerland

[4]Breast Centre St.Gallen, Cantonal Hospital, St. Gallen, Switzerland

关键词: Mammography screening programme;    Public health;    Mastectomy;    Epidemiology;    Breast cancer;    Switzerland;   

DOI  :  10.1186/s12885-021-07917-2

来源: Springer

【 摘 要 】

BackgroundA recent study found an influence of organized mammography screening programmes (MSPs) on geographical and temporal variation of mastectomy rates. We aimed to quantify the effect on the example of one of the cantonal programmes in Switzerland.MethodsWe used incidence data for the years 2010–2017 from the cancer registry of Eastern Switzerland. We included women with invasive-non-metastatic breast cancer (BC) in the screening age group 50–69-year-olds in the canton of St.Gallen. We compared mastectomy rates among cancer patients detected through the organised screening programme (MSP) vs. otherwise detected by stage.ResultsMSP-detected patients in St.Gallen presented with lower stages. 95% of MSP-detected had stages I-II vs 76% of Non-MSP-detected. Within all non-metastatic stage, tumour size and nodal status groups, MSP-detected patients had lower mastectomy rates, overall 10% vs 24% in 50–69-year-old non-participants. Their odds of receiving a mastectomy are about half of the Non-MSP-detected (OR = 0.48, p = 0.002).ConclusionsOur study showed that MSPs have a positive effect on lowering mastectomy rates. Screening participants are significantly less likely to receive a mastectomy compared to non-participants, which must be attributed to additional factors than just lower stages. Lower mastectomy rates lead to a higher quality of life for many patients.

【 授权许可】

CC BY