Anti-transcription intermediary factor 1 gamma (TIF1γ) antibody-positive dermatomyositis associated with ascending colon cancer: a case report and review of the literature

Journal of Medical Case Reports

Izumi Kitagawa¹  Tomohiro Kumagae¹  Mari Igasaki¹  Ryohei Ono¹  Masaki Yoshizawa²  Takaaki Murata³ 

[1] Department of General Internal Medicine, Shonan Kamakura General Hospital, 1370-1 Okamoto, 247-8533, Kamakura, Kanagawa, Japan;Department of Rheumatology, Shonan Kamakura General Hospital, 1370-1 Okamoto, 247-8533, Kamakura, Kanagawa, Japan;Department of Surgery, Shonan Kamakura General Hospital, 1370-1 Okamoto, 247-8533, Kamakura, Kanagawa, Japan;

关键词: Dermatomyositis;    Anti-transcription intermediary factor 1 gamma;    Anti-TIF1γ antibody;    Cancer;    Malignancy;   

DOI  :  10.1186/s13256-021-02664-1

来源: Springer

【 摘 要 】

BackgroundAnti-transcriptional intermediary factor 1 gamma (TIF1γ) antibody is a marker for predicting cancer association in patients with dermatomyositis (DM). The overall survival rate in DM patients with cancer was reported to be considerably worse than that in DM patients without cancer. However, the treatment for cancer-associated DM remains controversial, because the treatment priority between surgical resection for the tumor and internal treatments, including glucocorticoids, immunosuppressive agents, and intravenous immune globulin, has not been established.Case presentationWe report the case of a 57-year-old Japanese man diagnosed with anti-TIF1γ antibody-positive DM associated with ascending colon cancer. His clinical symptoms included facial and brachial edema, muscle weakness, dysphagia, myalgia, and rash. Physical examination revealed periorbital edema and Gottron's papules over his knuckles with brachial edema, and tenderness and weakness of the proximal limb muscles. The findings of hyperintense muscles in T2-weighted sequences of brachial contrast-enhanced magnetic resonance imaging and the infiltration of lymphocytic cells and CD4-positive lymphocytes from muscle biopsy were compatible with the diagnostic criteria for dermatomyositis. Anti-TIF1γ antibody was positive by immunoprecipitation assay. He first started internal treatment including intravenous immunoglobulin, steroid pulse, prednisolone, and azathioprine, followed by surgical resection for the tumor because of the elevation of creatine kinase and progression of dysphagia. However, clinical symptoms did not improve, and the patient died 6 months later.ConclusionsWe faced difficulties in determining the treatment priority between surgical resection and internal treatment for our case; therefore, this case would be educational for readers. We searched PubMed to identify English-language case reports of anti-TIF1γ antibody-positive dermatomyositis with malignancy and found 21 reported cases. We herein review and summarize previously reported cases of anti-TIF1γ antibody-positive DM with malignancy. Cancer screening is essential in patients with anti-TIF1γ antibody-positive dermatomyositis because it is associated with a high prevalence of malignancies. Our review revealed that initial surgical treatment should be recommended for better prognosis if the general condition allows.

【 授权许可】

CC BY