Using EEG and MEG to characterize extreme delta brush in a patient with anti-NMDA receptor encephalitis

BMC Neurology

Yongwei Shi¹  Chuanyong Yu²  Di Wu²  Xiaoshan Wang²  Yuanwen Yu²  Jianqing Ge²  Ailiang Miao³  Jing Xiang⁴  Qiqi Chen⁵ 

[1] Department of Neurology, Taizhou Fourth People’s Hospital, Taizhou, Jiangsu, China;Department of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing Medical University, Guang Zhou Road 264, 210029, Nanjing, Jiangsu, China;Department of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing Medical University, Guang Zhou Road 264, 210029, Nanjing, Jiangsu, China;Department of Video-Electroencephalogram, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, Jiangsu, China;MEG Center, Division of Neurology, Cincinnati Children’s Hospital Medical Center, 45220, Cincinnati, OH, USA;MEG Center, Nanjing Brain Hospital, 210029, Nanjing, Jiangsu, China;

关键词: anti-N-methyl-d-aspartate receptor encephalitis;    Electroencephalography;    Magnetoencephalography;    Extreme delta brush;   

DOI  :  10.1186/s12883-021-02157-0

来源: Springer

【 摘 要 】

BackgroundExtreme delta brush (EDB) is considered a potential marker for anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis. The brain regions involved in EDB are unclear.Case presentationA 16-year-old woman with anti-NMDAR encephalitis who was experiencing psychosis was admitted. Electroencephalography (EEG) and magnetoencephalography (MEG) were used to analyze EDB in the patient. EDB on EEG could be disturbed by opening and closing the eyes, by occipital alpha rhythms and by sleep-wake cycles. The MEG results showed beta activity originating from bilateral superior parietal lobes. However, the delta wave originated from bilateral superior temporal gyri, the right middle temporal gyrus, the right inferior frontal gyrus, and the left inferior parietal lobe.ConclusionsDelta wave and beta activity might originate from different brain regions. Beta activity might be transmitted forward to the frontotemporal lobe and superimposed with delta activity to form EDB on EEG.

【 授权许可】

CC BY