In respond to commensal bacteria: γδT cells play a pleiotropic role in tumor immunity

Cell & Bioscience

Yongting Liu¹  Ying Han²  Shan Zeng³  Hong Shen³ 

[1] Department of Oncology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China;Department of Oncology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China;National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, P.R. China;Department of Oncology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China;National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, P.R. China;Key Laboratory for Molecular Radiation Oncology of Hunan Province, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China;

关键词: Γδ T cells;    Commensal bacteria;    Protumor effects;    Antitumor effects;    Immunity therapy;   

DOI  :  10.1186/s13578-021-00565-w

来源: Springer

【 摘 要 】

γδT cells are a mixture of innate programming and acquired adaptability that bridge the adaptive and innate immune systems. γδT cells are mainly classified as tissue-resident Vδ1 or circulating Vδ2 γδT cells. In the tumor microenvironment, tumor immunity is influenced by the increased quantity and phenotype plasticity of γδT cells. Commensal bacteria are ubiquitous in the human body, and they have been confirmed to exist in various tumor tissues. With the participation of commensal bacteria, γδT cells maintain homeostasis and are activated to affect the development and progression of tumors. Here, we summarize the relationship between γδT cells and commensal bacteria, the potential protumor and antitumor effects underlying γδT cells, and the new developments in γδT cell-based tumor therapy which is expected to open new opportunities for tumor immunotherapy.

【 授权许可】

CC BY