Assessment of cerebral hemodynamics in multiple sclerosis patients

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery

Lobna M. ELnabil¹  Ahmed M. Elsadek¹  Azza A. Abdelaziz¹  Nouran M. Salah¹  Ayman M. Nassef¹  Mohamed A. Abdel Hafeez¹ 

[1] Neurology Department, Ain Shams University, Cairo, Egypt;

关键词: Multiple sclerosis;    Cerebral hemodynamics;    Demyelinating disorders;    Transcranial color-coded Doppler;    Autonomic dysfunction;    Cerebral vasomotor reactivity;   

DOI  :  10.1186/s41983-021-00291-7

来源: Springer

【 摘 要 】

BackgroundMultiple sclerosis (MS) is the most common demyelinating disease of the central nervous system. Autonomic dysfunction is present in a wide range of patients (15–80%) that might present with abnormalities in the regulation of the cardiovascular system, sleep disturbance, urinary symptoms, sexual problems, and temperature regulation problem. Although the predominant view is that of an autoimmune inflammatory condition, changes in brain vasculature can occur and contribute to pathophysiology.ObjectivesThe aim of this study was to evaluate cerebral hemodynamics and assess autonomic dysfunction in patients with MS and explore its relationship with disease status.MethodsEighty patients diagnosed with MS according to McDonald criteria 2017 were recruited to this comparative cross-sectional study. All participants underwent assessment of cerebral hemodynamics through transcranial Doppler ultrasonography. Cerebral vasomotor reactivity (CVR) to hypercapnia was measured by the breath-holding index (BHI). They were also assessed for autonomic dysfunction by autonomic questionnaire and blood pressure measurements in both erect and supine positions.ResultsBHI values showed decreased CVR and were significantly lower in SPMS than in RRMS patients. Autonomic functions were more affected in SPMS than RRMS with total score 2.58 ± 1.13 for the RRMS group and 4.05 ± 1.04 for the SPMS group.ConclusionsCerebrovascular hemodynamic insufficiency in MS may be secondary to the downstream effects of neuro-inflammatory cascades.

【 授权许可】

CC BY