Neuropsin in mental health

The journal of physiological sciences

article

Lina Bukowski¹  Ana M. F. Chernomorchenko¹  Anna Starnawska¹  Ole Mors¹  Nicklas H. Staunstrup¹  Anders D. Børglum¹  Per Qvist¹ 

[1] The Lundbeck Foundation Initiative for Integrative Psychiatric Research;Department of Biomedicine, Aarhus University;Center for Genomics and Personalized Medicine, Aarhus University;Psychosis Research Unit, Aarhus University Hospital;Department of Clinical Medicine, Aarhus University

关键词: Neuropsin;    KLK8;    Mental disorders;    Mental health;    Biomarker;    Human;    Depression;    Extracellular matrix;    LTP;    Gene expression;   

DOI  :  10.1186/s12576-020-00753-2

来源: Springer

【 摘 要 】

Neuropsin is a brain-expressed extracellular matrix serine protease that governs synaptic plasticity through activity-induced proteolytic cleavage of synaptic proteins. Its substrates comprise several molecules central to structural synaptic plasticity, and studies in rodents have documented its role in cognition and the behavioral and neurobiological response to stress. Intriguingly, differential usage of KLK8 (neuropsin gene) splice forms in the fetal and adult brain has only been reported in humans, suggesting that neuropsin may serve a specialized role in human neurodevelopment. Through systematic interrogation of large-scale genetic data, we review KLK8 regulation in the context of mental health and provide a summary of clinical and preclinical evidence supporting a role for neuropsin in the pathogenesis of mental illness.

【 授权许可】

Unknown