Regulation of tumor infiltrated innate immune cells by adenosine

Purinergic signalling

article

Regina Strakhova¹  Octavia Cadassou¹  Emeline Cros-Perrial¹  Lars Petter Jordheim¹ 

[1] Université Claude Bernard Lyon 1, Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon

关键词: Adenosine;    Cancer;    Microenvironment;    Inflammation;    Macrophages;    NK cells;    Neutrophils;    Mast cells;    Dendritic cells;   

DOI  :  10.1007/s11302-020-09701-6

学科分类：分子生物学，细胞生物学和基因

来源: Springer

【 摘 要 】

Cancer has the ability to escape the immune system using different molecular actors. Adenosine is known to be involved in mechanisms which control inflammatory reactions and prevent excessive immune response. This purine nucleoside can be translocated from the cell or produced in the extracellular space by 5′-ectonucleotidases. Once bound to its receptors on the surface of immune effector cells, adenosine activates various molecular pathways, which lead to functional inhibition of the cell or its death. Some tumors are infiltrated by the different cells of immune system but are able to use adenosine as an immunosuppressive molecule and thus inhibit immune anticancer response. This mechanism is well described on adaptive cells, but much less on innate cells. This review outlines major effects of adenosine on innate immune cells, its consequences on cancer progression, and possible ways to block the adenosine-dependent immunosuppressive effect.

【 授权许可】

CC BY