Cardiotoxicity: a challenge for modern oncology

Cardiometry

article

Oleg I. Kit¹  Elena M. Frantsiyants¹  Elena A. Dzhenkova¹  Oksana V. Katelnitskaya¹  Alla I. Shikhlyarova¹  Aleksandr B. Sagakyants¹  Ekaterina V. Verenikina¹  Yuriy А. Gevorkyan¹  Yuriy А. Fomenko¹  Vladimir S. Trifanov¹  Aleksey N. Shevchenko¹ 

[1] Rostov Research Institute of Oncology, Ministry of Healthcare of the Russian Federation

关键词: Cardiotoxicity;    Cardiopathology;    Carcinogenesis;    Trastuzumab;    Tissue homeostasis;    Antitumor effect;   

DOI  :  10.12710/cardiometry.2018.13.814

学科分类：环境科学（综合）

来源: Russian New University

【 摘 要 】

The article provides a modern vision of the problem of cardiotoxicity in oncology. Integrity and generality of nodal pathogenetic events in the body in case of carcinogenesis, antitumor therapy and cardiopathology are caused by similar mechanisms at different hierarchical levels. Identity of potential risk factors, including inflammation, aging, obesity, diabetes and smoking, has been noted. Similarly, in the development of metabolic syndrome and carcinogenesis, the level of growth factors (IGF-1), neoangiogenesis, hormones and other triggers of oncological and cardiovascular pathology is increasing. It is important that a variety of clinical manifestations of cardiotoxicity are due to the rapid expansion of the number of therapeutic options for effects. This thesis is illustrated by vivid examples of the use of anthracycline-based drugs whose mechanism of action is aimed at damaging genetic targets. The use of monoclonal antibodies - trastuzumab, is directed against HER2 / ErB2 receptors in breast cancer and is accompanied by distinct signs of cardiotoxicity especially in the elderly. A new strategy to enhance the targeted cytotoxic immune response to cancer cells (Ipilimumab, Nivolumab) has a chance to cause autoimmune myocarditis and myositis. Modern anti-angiogenic methods of cancer therapy, including inhibition of VEGF, significantly increase the risk of myocardial ischemia, hypertension and atherosclerosis. This indicates the need for monitoring of complications, a targeted selection of preventive and curative strategies, as well as attention to the mechanisms of tissue homeostasis in the implementation of the antitumor effect.

【 授权许可】

CC BY