Distinct effect of body mass index by sex as a prognostic factor in localized renal cell carcinoma treated with nephrectomy ~ data from a multi-institutional study in Japan ~

BMC Cancer

Kiyoshi Takahara¹  Takeshi Tsutsumi²  Koichiro Minami²  Haruhito Azuma²  Tomoaki Takai²  Naokazu Ibuki²  Takuya Tsujino²  Hajime Hirano²  Tomohisa Matsunaga²  Hirofumi Uehara²  Hayahito Nomi²  Teruo Inamoto²  Yuki Yoshikawa²  Kazumasa Komura³  Naoya Satake⁴  Takeshi Hashimoto⁴  Yoshio Ohno⁴  Ryu Muraoka⁴  Tomohito Tanaka⁵  Kohei Taniguchi⁵ 

[1] Department of Urology, Fujita-Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake, Toyoake, Aichi, Japan;Department of Urology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki City, 569-8686, Osaka, Japan;Department of Urology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki City, 569-8686, Osaka, Japan;Translational Research Program, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki City, 569-8686, Osaka, Japan;Department of Urology, Tokyo Medical University, 6-7-1 Nishi-shinjuku, Shinjuku-ku, 160-0023, Tokyo, Japan;Translational Research Program, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki City, 569-8686, Osaka, Japan;

关键词: Renal cell carcinoma;    Body mass index;    Sex;    Prognostic factor;   

DOI  :  10.1186/s12885-021-07883-9

来源: Springer

【 摘 要 】

BackgroundWe assessed the prognostic value of body mass index (BMI) in Asian patients with localized RCC who underwent nephrectomy.MethodsA total of 665 patients who underwent nephrectomy for localized RCC were enrolled in the present study and divided into the two BMI groups: i.e., BMI < 25 in 463 (69.6%) and BMI > 25 in 202 (30.4%) patients.ResultsIn total, there were 482 (72.5%) males and 183 (27.5%) females. Five-year cancer-specific survival (CSS) rates were significantly higher in increased BMI than the lower BMI group (97.1 and 92.5%: P = 0.007). When stratified by sex, significantly longer CSS in higher BMI was confirmed in males (5-year CSS of 92.7% in BMI < 25 and 98.1% in BMI > 25, p = 0.005), while there was no difference in CSS between BMI groups for female patients. Multivariable analysis exhibited that higher BMI was an independent predictor for favorable CSS in male (cox model: p = 0.041, Fine & Gray regression model: p = 0.014), but not in the female. Subgroup analysis for CSS revealed that favorable CSS with higher BMI was observed in patient subgroups of age < 65 (p = 0.019), clear cell histology (p = 0.018), and tumor size > 4 cm, p = 0.020) as well as male (p = 0.020).ConclusionOur findings collected from the multi-institutional Japanese dataset demonstrated longer survival in patients with higher BMI than lower BMI for non-metastatic RCC treated with nephrectomy. Intriguingly, this finding was restricted to males, but not to females.

【 授权许可】

CC BY