Hyperhomocysteinemia and its relations to conventional risk factors for cardiovascular diseases in adult Nigerians: the REMAH study

BMC Cardiovascular Disorders

Augustine N. Odili¹  BenjaminDanladi¹  Maxwell M. Nwegbu²  Adewale L. Alli³  Bassey A. Inyang³  Michael P. Okoh³  Babangida S. Chori⁴ 

[1]Circulatory Health Research Laboratory, Old Anatomy Block (Beside School of Nursing and Midwifery), University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria

[2]Department of Chemical Pathology, College of Health Sciences, Faculty of Basic Clinical Sciences, University of Abuja, Abuja, Nigeria

[3]Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Health Sciences, University of Abuja, Abuja, Nigeria

[4]Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Health Sciences, University of Abuja, Abuja, Nigeria

[5]Circulatory Health Research Laboratory, Old Anatomy Block (Beside School of Nursing and Midwifery), University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria

关键词: Hyperhomocysteinemia;    High-density lipoprotein;    Blood pressure;    Cardiovascular diseases risk factors;   

DOI  :  10.1186/s12872-021-01913-x

来源: Springer

【 摘 要 】

BackgroundEvidence linking homocysteine (Hcy) with cardiovascular diseases (CVD) or its risk factors are limited in a sub-Saharan black population.ObjectiveWe set out to evaluate the association between Hcy and hypertension and other CVD risk factors in a population of adult Nigerians.MethodsData of 156 adults aged 18–70 years was accessed from the North Central study site of the REmoving the MAsk on Hypertension (REMAH) study. Homocysteine, blood glucose and lipid profile in whole blood/serum were measured using standard laboratory methods. Hypertension was diagnosed if average of 5 consecutive blood pressure (BP) measurements obtained using a mercury sphygmomanometer was equal to or higher than 140 systolic and/or 90 mmHg diastolic or the individual is on antihypertensive medication. Hyperhomocysteinemia (HHcy) was defined as Hcy > 10 µmol/L.ResultsOf the 156 participants, 72 (43.5%) were hypertensive, of whom 18 had HHcy. Subjects with HHcy were significantly (p < 0.05) older (41.5 vs. 40.6yrs), had lower HDL-cholesterol (0.6 vs. 0.8 mmol/L) and higher systolic (145.5 vs. 126.0 mmHg) and diastolic BP (92.9 vs. 79.6 mmHg), compared to those without HHcy. Intake of alcohol and a 1 yr increase in age were respectively and significantly (p < 0.05) associated with a 1.54 and 0.10 µmol/L increase in Hcy. In a multivariable model adjusted for age, sex and body mass index, a 1 µmol/L increase in Hcy, was associated with a 1.69 mmHg and 1.34 mmHg increase in systolic and diastolic pressure (p < 0.0001) respectively; and a 0.01 mmol/L decrease in HDL-cholesterol (p < 0.05).ConclusionHHcy occurs among hypertensive Nigerians and it is independently associated with age, HDL-cholesterol, systolic and diastolic BP.

【 授权许可】

CC BY