Feasibility of a multimodal exercise, nutrition, and palliative care intervention in advanced lung cancer

BMC Cancer

Audra Arlain¹  Jennifer Black²  Chelsia Gillis³  Gwyn Bebb⁴  Lyle Galloway⁵  Amane Abdul-Razzak⁶  George Francis⁷  Julia T. Daun⁸  Delaney Duchek⁸  Manuel Ester⁸  S. Nicole Culos-Reed⁹  Lauren C. Capozzi^1,10 

[1] Cancer Control Alberta, Alberta Health Services, Calgary, Alberta, Canada;Cancer Control Alberta, Alberta Health Services, Calgary, Alberta, Canada;Nutrition Services, Foothills Medical Centre, Cancer Care & Alberta Healthy Living Program, Calgary, Alberta, Canada;Community Health Sciences, University of Calgary, Calgary, Alberta, Canada;Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada;Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada;Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada;Department of Family Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada;Division of Palliative Medicine, Department of Oncology, University of Calgary, Calgary, Alberta, Canada;Division of Physical Medicine and Rehabilitation, Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada;Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada;Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada;Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada;Department of Psychosocial Resources, Tom Baker Cancer Centre, Calgary, Alberta, Canada;Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada;Division of Physical Medicine and Rehabilitation, Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada;

关键词: Exercise oncology;    Supportive cancer care;    Quality of life;    Advanced lung cancer;    Nutrition;    Symptom management;   

DOI  :  10.1186/s12885-021-07872-y

来源: Springer

【 摘 要 】

BackgroundAdvanced lung cancer patients face significant physical and psychological burden leading to reduced physical function and quality of life. Separately, physical activity, nutrition, and palliative symptom management interventions have been shown to improve functioning in this population, however no study has combined all three in a multimodal intervention. Therefore, we assessed the feasibility of a multimodal physical activity, nutrition, and palliative symptom management intervention in advanced lung cancer.MethodsParticipants received an individually tailored 12-week intervention featuring in-person group-based exercise classes, at-home physical activity prescription, behaviour change education, and nutrition and palliative care consultations. Patients reported symptom burden, energy, and fatigue before and after each class. At baseline and post-intervention, symptom burden, quality of life, fatigue, physical activity, dietary intake, and physical function were assessed. Post-intervention interviews examined participant perspectives.ResultsThe multimodal program was feasible, with 44% (10/23) recruitment, 75% (75/100) class attendance, 89% (8/9) nutrition and palliative consult attendance, and 85% (17/20) assessment completion. Of ten participants, 70% (7/10) completed the post-intervention follow-up. Participants perceived the intervention as feasible and valuable. Physical activity, symptom burden, and quality of life were maintained, while tiredness decreased significantly. Exercise classes prompted acute clinically meaningful reductions in fatigue, tiredness, depression, pain, and increases in energy and well-being.ConclusionA multimodal physical activity, nutrition, and palliative symptom management intervention is feasible and shows potential benefits on quality of life that warrant further investigation in a larger cohort trial.Trial registrationNCT04575831, Registered 05 October 2020 – Retrospectively registered.

【 授权许可】

CC BY