“EXHALE”: exercise as a strategy for rehabilitation in advanced stage lung cancer patients: a randomized clinical trial comparing the effects of 12 weeks supervised exercise intervention versus usual care for advanced stage lung cancer patients

BMC Cancer

Morten Quist¹  Seppo W Langer⁴  Mikael Rørth⁴  Karl Bang Christensen²  Lis Adamsen³ 

[1] Centre for Integrated Rehabilitation of Cancer Patients (CIRE), Copenhagen, Denmark

[2] Department of Biostatistics, University of Copenhagen, Copenhagen, Denmark

[3] Institute of Public Health, University of Copenhagen, Copenhagen, Denmark

[4] Department of Oncology, Copenhagen University Hospital Rigshospitalet, 5073 Copenhagen, Denmark

关键词: Chemotherapy;    Advanced lung cancer;    Depression;    Anxiety;    Quality of life;    Exercise;    Functional capacity;    Maximal oxygen uptake (VO₂peak);   

Others  :  1079515
DOI  :  10.1186/1471-2407-13-477

 received in 2013-06-25, accepted in 2013-10-03,  发布年份 2013

【 摘 要 】

Background

Lung cancer is the leading cause of cancer death in North America and Western Europe. Patients with lung cancer in general have reduced physical capacity, functional capacity, poor quality of life and increased levels of anxiety and depression. Intervention studies indicate that physical training can address these issues. However, there is a lack of decisive evidence regarding the effect of physical exercise in patients with advanced lung cancer. The aim of this study is to evaluate the effects of a twelve weeks, twice weekly program consisting of: supervised, structured training in a group of advanced lung cancer patients (cardiovascular and strength training, relaxation).

Methods/Design

A randomized controlled trial will test the effects of the exercise intervention in 216 patients with advanced lung cancer (non-small cell lung cancer (NSCLC) stage IIIb - IV and small cell lung cancer (SCLC) extensive disease (ED)). Primary outcome is maximal oxygen uptake (VO₂peak). Secondary outcomes are muscle strength (1RM), functional capacity (6MWD), lung capacity (Fev1) and patient reported outcome (including anxiety, depression (HADS) and quality of life (HRQOL)).

Discussion

The present randomized controlled study will provide data on the effectiveness of a supervised exercise intervention in patients receiving systemic therapy for advanced lung cancer. It is hoped that the intervention can improve physical capacity and functional level, during rehabilitation of cancer patients with complex symptom burden and help them to maintain independent function for as long as possible.

Trial registration

http://ClinicalTrials.gov, NCT01881906 webcite

【 授权许可】

   
2013 Quist et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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