BMC Research Notes | |
Could dysbiosis of inflammatory and anti-inflammatory gut bacteria have an implications in the development of type 2 diabetes? A pilot investigation | |
Indranil Chattopadhyay1  Prasanna Kulkarni2  Poornima Devkumar2  | |
[1] Department of Life Sciences, Central University of Tamil Nadu, 610005, Thiruvarur, India;Institute of Ayurveda and Integrative Medicine (I-AIM), Bangalore, India; | |
关键词: Gut microbiota; Type 2 diabetes; Inflammation; Diagnostic marker; | |
DOI : 10.1186/s13104-021-05466-2 | |
来源: Springer | |
【 摘 要 】
ObjectiveDifferential alterations in gut microbiota and chronic low-grade inflammation play a critical role in the development of Type 2 diabetes (T2D). Here we aimed to investigate if dysbiosis of inflammation and anti-inflammation-associated gut bacterial communities in fecal samples of individuals had any influence on T2D using a 16S rRNA gene of V3 region sequencing at Illumina MiSeq platform.ResultsOur findings showed that a higher abundance of inflammatory bacteria such as Lactobacillus ruminis, Ruminococcus gnavus, Bacteroides caccae, Butyricimonas, and Collinsella aerofaciens, and lower abundance of anti-inflammatory bacteria such as Faecalibacterium prausnitzii, and Butyrivibrio that likely play a role in the development of T2D. Our findings hint the potential of indigenous microbiota in developing diagnostic markers and therapeutic targets in T2D.
【 授权许可】
CC BY
【 预 览 】
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RO202106288060104ZK.pdf | 1379KB | download |