Could dysbiosis of inflammatory and anti-inflammatory gut bacteria have an implications in the development of type 2 diabetes? A pilot investigation

BMC Research Notes

Indranil Chattopadhyay¹  Prasanna Kulkarni²  Poornima Devkumar² 

[1] Department of Life Sciences, Central University of Tamil Nadu, 610005, Thiruvarur, India;Institute of Ayurveda and Integrative Medicine (I-AIM), Bangalore, India;

关键词: Gut microbiota;    Type 2 diabetes;    Inflammation;    Diagnostic marker;   

DOI  :  10.1186/s13104-021-05466-2

来源: Springer

【 摘 要 】

ObjectiveDifferential alterations in gut microbiota and chronic low-grade inflammation play a critical role in the development of Type 2 diabetes (T2D). Here we aimed to investigate if dysbiosis of inflammation and anti-inflammation-associated gut bacterial communities in fecal samples of individuals had any influence on T2D using a 16S rRNA gene of V3 region sequencing at Illumina MiSeq platform.ResultsOur findings showed that a higher abundance of inflammatory bacteria such as Lactobacillus ruminis, Ruminococcus gnavus, Bacteroides caccae, Butyricimonas, and Collinsella aerofaciens, and lower abundance of anti-inflammatory bacteria such as Faecalibacterium prausnitzii, and Butyrivibrio that likely play a role in the development of T2D. Our findings hint the potential of indigenous microbiota in developing diagnostic markers and therapeutic targets in T2D.

【 授权许可】

CC BY