Cytosolic delivery of nucleic acids: The case of ionizable lipid nanoparticles

Bioengineering & Translational Medicine

Gabriella Costabile¹  Roberto Palomba¹  Martina Pannuzzo¹  Paolo Decuzzi¹  Michele Schlich²  Shoshy Mizrahy³  Dan Peer⁴ 

[1] Fondazione Istituto Italiano di Tecnologia, Laboratory of Nanotechnology for Precision Medicine, Genoa, Italy;Fondazione Istituto Italiano di Tecnologia, Laboratory of Nanotechnology for Precision Medicine, Genoa, Italy;Department of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy;Fondazione Istituto Italiano di Tecnologia, Laboratory of Nanotechnology for Precision Medicine, Genoa, Italy;Laboratory of Precision NanoMedicine, Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel;Department of Materials Sciences and Engineering, Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel;Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv, Israel;Cancer Biology Research Center, Tel Aviv University, Tel Aviv, Israel;Laboratory of Precision NanoMedicine, Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel;Department of Materials Sciences and Engineering, Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel;Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv, Israel;Cancer Biology Research Center, Tel Aviv University, Tel Aviv, Israel;

关键词: endosomal escape;    intracellular delivery;    ionizable lipids;    LNPs;    mRNA;    RNA delivery;    siRNA;   

DOI  :  10.1002/btm2.10213

来源: Wiley

【 授权许可】

CC BY