Important Considerations Related to Permeability of Peptides

CHIMIA

Thomas E. Vorherr¹ 

[1] Novartis Pharma AG, WSJ 507.8.52, CH-4056 Basel, Switzerland;

关键词: intracellular delivery;    metabolism;    oral bioavailability;    permeability;    pharmacokinetics;   

DOI  :  10.2533/chimia.2021.522

来源: DOAJ

【 摘 要 】

This review on intracellular delivery and oral bioavailability of peptides reflects a number of principal investigations at Novartis. Our studies were aimed at either understanding features enabling peptides to interfere with intracellular protein–protein interactions, or to achieve a more patient-friendly delivery by the oral route. In the light of these objectives, we have also spent some effort on assay development to come up with alternative methods for monitoring cellular peptide uptake. This summary of our insights is intended to help in the assessment and development of peptide therapeutics requiring membrane transition

【 授权许可】

Unknown