PRMT5 Enables Robust STAT3 Activation via Arginine Symmetric Dimethylation of SMAD7

Advanced Science

Bo Yuan¹  Bing Yang¹  HanChenxi Zhang¹  Yezhang Zhu¹  Li Shen¹  Congcong Cai²  Yi Yu²  Shuchen Gu²  Xin‐Hua Feng³ 

[1] The MOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, 310058, China;The MOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, 310058, China;The Key Laboratory of Cancer Molecular Cell Biology of Zhejiang Province, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, 310058, China;The MOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, 310058, China;The Key Laboratory of Cancer Molecular Cell Biology of Zhejiang Province, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, 310058, China;The Second Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, 310009, China;

关键词: methylation;    migration;    PRMT5;    proliferation;    Smad7;    STAT3;   

DOI  :  10.1002/advs.202003047

来源: Wiley

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