Senescence‐associated β‐galactosidase reveals the abundance of senescent CD8+ T cells in aging humans

Aging Cell

Ricardo I. Martínez‐Zamudio¹  Utz Herbig¹  Themistoklis Vasilopoulos²  Patricia Fitzgerald‐Bocarsly³  Lisa Gittens‐Williams⁴  Hannah K. Dewald⁵ 

[1] Center for Cell Signaling, Rutgers‐New Jersey Medical School, Rutgers Biomedical and Health Sciences, Rutgers University, Newark, New Jersey, USA;Department of Microbiology, Biochemistry, and Molecular Genetics, Rutgers‐New Jersey Medical School, Rutgers Biomedical and Health Sciences, Rutgers University, Newark, New Jersey, USA;Center for Cell Signaling, Rutgers‐New Jersey Medical School, Rutgers Biomedical and Health Sciences, Rutgers University, Newark, New Jersey, USA;Department of Microbiology, Biochemistry, and Molecular Genetics, Rutgers‐New Jersey Medical School, Rutgers Biomedical and Health Sciences, Rutgers University, Newark, New Jersey, USA;Rutgers School of Graduate Studies, Rutgers‐New Jersey Medical School, Rutgers Biomedical and Health Sciences, Rutgers University, Newark, New Jersey, USA;Center for Immunity and Inflammation, Rutgers‐New Jersey Medical School, Rutgers Biomedical and Health Sciences, Rutgers University, Newark, New Jersey, USA;Department of Pathology, Immunology, and Laboratory Medicine, Rutgers‐New Jersey Medical School, Rutgers Biomedical and Health Sciences, Rutgers University, Newark, New Jersey, USA;Department of Obstetrics, Gynecology and Women's Health, Rutgers‐New Jersey Medical School, Rutgers Biomedical and Health Sciences, Rutgers University, Newark, New Jersey, USA;Rutgers School of Graduate Studies, Rutgers‐New Jersey Medical School, Rutgers Biomedical and Health Sciences, Rutgers University, Newark, New Jersey, USA;Center for Immunity and Inflammation, Rutgers‐New Jersey Medical School, Rutgers Biomedical and Health Sciences, Rutgers University, Newark, New Jersey, USA;Department of Pathology, Immunology, and Laboratory Medicine, Rutgers‐New Jersey Medical School, Rutgers Biomedical and Health Sciences, Rutgers University, Newark, New Jersey, USA;

关键词: aging;    cellular senescence;    immunosenescence;    lymphocytes;    p16;    PBMC;    senescence‐associated β‐galactosidase;    T cells;    telomere;   

DOI  :  10.1111/acel.13344

来源: Wiley

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