uPA‐PAI‐1 heteromerization promotes breast cancer progression by attracting tumorigenic neutrophils

EMBO Molecular Medicine

Christian Schulz¹  Jörg Heil²  Matthias Mack³  Martin Canis⁴  Laura A Mittmann⁵  Constanze Braun⁵  Julian Dominik⁵  Bernd Uhl⁵  Christoph A Reichel⁵  Bojan Smiljanov⁵  Johanna B Schaubächer⁵  Florian Haring⁵  Lena Padovan⁵  Katja Steiger⁶  Wilko Weichert⁷  Kirsten Lauber⁸  Roman Hennel⁸  Ewgenija Gutjahr⁹  Peter Sinn⁹  Sandip M Kanse^1,10  Markus Sperandio^1,11  Robert Pick^1,12  Fritz Krombach^1,12 

[1] Department of Cardiology, University Hospital, Ludwig‐Maximilians‐Universität München, Munich, Germany;Department of Gynecology and Obstetrics, University of Heidelberg, Heidelberg, Germany;Department of Internal Medicine, University of Regensburg, Regensburg, Germany;Department of Otorhinolaryngology, University Hospital, Ludwig‐Maximilians‐Universität München, Munich, Germany;Department of Otorhinolaryngology, University Hospital, Ludwig‐Maximilians‐Universität München, Munich, Germany;Walter Brendel Centre of Experimental Medicine, University Hospital, Ludwig‐Maximilians‐Universität München, Munich, Germany;Department of Pathology, Technical University of Munich, Munich, Germany;Department of Pathology, Technical University of Munich, Munich, Germany;German Cancer Consortium (DKTK), partner site Munich, Ludwig‐Maximilians‐Universität München, Munich, Germany;Department of Radiation Oncology, University Hospital, Ludwig‐Maximilians‐Universität München, Munich, Germany;Institute for Pathology, University of Heidelberg, Heidelberg, Germany;Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway;Institute of Cardiovascular Physiology and Pathophysiology, Ludwig‐Maximilians‐Universität München, Munich, Germany;Walter Brendel Centre of Experimental Medicine, University Hospital, Ludwig‐Maximilians‐Universität München, Munich, Germany;

关键词: biomarker;    breast cancer;    fibrinolysis;    innate immunity;    neutrophils;   

DOI  :  10.15252/emmm.202013110

来源: Wiley

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