Natural variants suppress mutations in hundreds of essential genes

Molecular Systems Biology

Elise Eray¹  Jolanda van Leeuwen¹  Maykel Lopes¹  Amandine Batté¹  Bryan‐Joseph San Luis²  Michael W Yuen²  Meredith Laver²  Leopold Parts³  Carles Pons⁴  Patrick Aloy⁵  Jia‐Xing Yue⁶  Gianni Liti⁶ 

[1] Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland;Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada;Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada;Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK;Department of Computer Science, University of Tartu, Tartu, Estonia;Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute for Science and Technology, Barcelona, Spain;Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute for Science and Technology, Barcelona, Spain;Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain;University of Côte d’Azur, CNRS, INSERM, IRCAN, Nice, France;

关键词: compensatory evolution;    genetic interactions;    genetic modifiers;    genetic suppression;    natural variation;   

DOI  :  10.15252/msb.202010138

来源: Wiley

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