Spermidine inhibits vascular calcification in chronic kidney disease through modulation of SIRT1 signaling pathway

Aging Cell

Qingchun Liang¹  Xiulin Yang²  Zirong Lan²  Jianyun Yan²  Xiaoyu Liu²  Pingzhen Yang²  Yuanzhi Ye²  Qianqian Dong²  Siyi Wang²  An Chen²  Mingwei Fu²  Yining Li²  Lihe Lu³  Yanting Chen³  Jing‐Song Ou⁴ 

[1] Department of Anesthesiology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China;Department of Cardiology, Laboratory of Heart Center, Heart Center, Zhujiang Hospital, Southern Medical University, Guangzhou, China;Guangdong Provincial Biomedical Engineering Technology Research Center for Cardiovascular Disease, Guangzhou, China;Sino‐Japanese Cooperation Platform for Translational Research in Heart Failure, Guangzhou, China;Department of Pathophysiolgy, Zhongshan School of Medicine, Sun Yat‐Sen University, Guangzhou, China;Division of Cardiac Surgery, The First Affiliated Hospital, Sun Yat‐Sen University, Guangzhou, China;

关键词: aging;    chronic kidney disease;    endoplasmic reticulum stress;    SIRT1;    spermidine;    vascular calcification;   

DOI  :  10.1111/acel.13377

来源: Wiley

【 授权许可】

CC BY