Age‐related telomere attrition causes aberrant gene expression in sub‐telomeric regions

Aging Cell

Judith Campisi¹  Tao Wang²  Zhidong Tu³  Shixiang Sun⁴  Cristina Montagna⁴  Lei Zhang⁵  Xiao Dong⁵  Alexander Y. Maslov⁶  Jan Vijg⁷  Seungsoo Kim⁸  Yousin Suh⁹ 

[1] Buck Institute for Research on Aging, Novato, CA, USA;Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, USA;Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine Mount Sinai, New York, NY, USA;Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA;Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA;Institute on the Biology of Aging and Metabolism, Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN, USA;Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA;Laboratory of Applied Genomic Technologies, Voronezh State University of Engineering Technology, Voronezh, Russia;Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA;School of Public Health, Center for Single‐Cell Omics, Shanghai Jiao Tong University School of Medicine, Shanghai, China;Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY, USA;Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY, USA;Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY, USA;

关键词: aging;    gene expression;    telomere shortening;   

DOI  :  10.1111/acel.13357

来源: Wiley

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CC BY