Spatially displaced excitation contributes to the encoding of interrupted motion by a retinal direction-selective circuit

eLife

Jennifer Ding¹  Wei Wei²  Stephanie E Palmer³  Mofei Wu⁴  Janet Chung⁴  David M Berson⁵  Albert Chen⁶  Hector Acaron Ledesma⁷ 

[1] Committee on Neurobiology Graduate Program, The University of Chicago, Chicago, United States;Department of Neurobiology, The University of Chicago, Chicago, United States;Committee on Neurobiology Graduate Program, The University of Chicago, Chicago, United States;Department of Neurobiology, The University of Chicago, Chicago, United States;Grossman Institute for Neuroscience, Quantitative Biology and Human Behavior, The University of Chicago, Chicago, United States;Committee on Neurobiology Graduate Program, The University of Chicago, Chicago, United States;Department of Organismal Biology, The University of Chicago, Chicago, United States;Grossman Institute for Neuroscience, Quantitative Biology and Human Behavior, The University of Chicago, Chicago, United States;Department of Neurobiology, The University of Chicago, Chicago, United States;Department of Neuroscience and Carney Institute for Brain Science, Brown University, Providence, United States;Department of Organismal Biology, The University of Chicago, Chicago, United States;Graduate Program in Biophysical Sciences, The University of Chicago, Chicago, United States;

关键词: direction selectivity;    visual motion;    retinal circuitry;    synaptic exciation;    dendrites;    direction-selective ganglion cells;    Mouse;   

DOI  :  10.7554/eLife.68181

来源: eLife Sciences Publications, Ltd

【 摘 要 】

Spatially distributed excitation and inhibition collectively shape a visual neuron’s receptive field (RF) properties. In the direction-selective circuit of the mammalian retina, the role of strong null-direction inhibition of On-Off direction-selective ganglion cells (On-Off DSGCs) on their direction selectivity is well-studied. However, how excitatory inputs influence the On-Off DSGC’s visual response is underexplored. Here, we report that On-Off DSGCs have a spatially displaced glutamatergic receptive field along their horizontal preferred-null motion axes. This displaced receptive field contributes to DSGC null-direction spiking during interrupted motion trajectories. Theoretical analyses indicate that population responses during interrupted motion may help populations of On-Off DSGCs signal the spatial location of moving objects in complex, naturalistic visual environments. Our study highlights that the direction-selective circuit exploits separate sets of mechanisms under different stimulus conditions, and these mechanisms may help encode multiple visual features.

【 授权许可】

CC BY