Anti-CV2/CRMP5 Paraneoplastic Chorea Effectively Managed with Intravenous Amantadine

Tremor and Other Hyperkinetic Movements

article

Jongmok Ha¹  Boo Suk Na³  Jong Hyeon Ahn¹  Minkyeong Kim¹  Jae Woo Kim⁴  Jae Hyeok Lee⁵  Jin Whan Cho¹  Ji Sun Kim¹  Jinyoung Youn¹ 

[1] Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine;Neuroscience Center, Samsung Medical Center;Department of Neurology, Dongshin Hospital;Department of Neurology, Dong-A University College of Medicine;Department of Neurology, Pusan National University Yangsan Hospital

关键词: Paraneoplastic;    autoimmune;    CRMP5;    CV2;    chorea;   

DOI  :  10.5334/tohm.483

学科分类：社会科学、人文和艺术（综合）

来源: Ubiquity Press

【 摘 要 】

Background: Paraneoplastic chorea is typically a subacute progressive hyperkinetic movement disorder. The mainstay of treatment is managing the underlying neoplasm. However, the clinical course may be variable, and effective symptomatic management can precede the start of cancer treatment. Case report: A 63-year-old man presented with insidious onset, slowly progressive generalized chorea for 1 year, later diagnosed as anti-CV2/CRMP5 autoantibody positive paraneoplastic chorea. His chorea was markedly improved with intravenous amantadine. Discussion: In patients with anti-CV2/CRMP5 autoantibody-related chorea, sequential follow-up of brain magnetic resonance imaging reveals progression from active inflammation to atrophy. Our report highlights the efficacy of intravenous amantadine in paraneoplastic chorea.

【 授权许可】

CC BY