Change in Non-motor Symptoms in Parkinson’s Disease and Essential Tremor Patients: A One-year Follow-up Study

Tremor and Other Hyperkinetic Movements

article

Maurizio Giorelli¹  Junia Bagnoli²  Luigi Consiglio²  Pasquale Difazio²  Daniela Zizza²  Giovanni Bosco Zimatore¹ 

[1] Operative Unit of Neurology, ‘‘Dimiccoli’’ General Hospital;Operative Unit of Nuclear Medicine, ‘‘Dimiccoli’’ General Hospital

关键词: Non-motor symptoms;    NMSQuest;    Parkinson’s disease;    essential tremor;    follow-up;   

DOI  :  10.5334/tohm.189

学科分类：社会科学、人文和艺术（综合）

来源: Ubiquity Press

【 摘 要 】

Background: Non-motor symptoms (NMS) in Parkinson’s disease (PD) differ from those in essential tremor (ET), even before a definitive diagnosis is made. It is not clear whether patient’s knowledge of the diagnosis and treatment influence their subsequent reporting of NMS. Methods: 1 year after a clinical and instrumental diagnosis, we compared the motor impairment (Movement Disorders Society (MDS)-Unified Parkinson’s Disease Rating Scale-III) and non-motor symptoms (NMSQuest) in PD (n=31) and ET (n=21) patients. Results: PD patients reported more NMS than did the ET patients (p=0.002). When compared to their baseline report, at follow-up, PD patients reported less nocturia (p=0.02), sadness (p=0.01), insomnia (p=0.02), and restless legs (p=0.04) and more nausea (p=0.024), unexplained pain (p=0.03), weight change (p=0.009), and daytime sleepiness (p=0.03). When compared to their baseline report, ET patients reported less loss of interest (p=0.03), anxiety (p=0.006), and insomnia (p=0.02). Differences in reported weight change (p<0.0001) and anxiety (p=0.001) between PD and ET patients were related to pharmacological side effects or to a reduction in the ET individuals. Discussion: The reporting of NMS is influenced by subjective factors, and might vary with the patient’s knowledge of the diagnosis or the effectiveness of treatment.

【 授权许可】

CC BY