Study of Toxic Effects of Oxothiazole Derivative as a New Antibacterial Agent

The Iranian Journal of Veterinary Science and Technology

article

Beyzaei, Hamid¹  Jamshidian, Abbas²  Hajinezhad, Mohammad Reza³  Hashemi, Seyed Hadi⁴  Amel, Nasim⁵  Abdollahi, Maliheh⁶  Arab-Sahebi, Fatemeh⁷  Ghasemi, Behzad⁶ 

[1] Department of Chemistry, Faculty of Science, University of Zabol;Department of Pathobiology, Faculty of Veterinary Medicine, University of Zabol;Department of Basic Sciences, Faculty of Veterinary Medicine, University of Zabol;Department of Clinical Sciences, Faculty of Veterinary Medicine, Zabol University;Torbat Heydariyeh University of Medical Sciences;Torbat Jam Faculty of Medical Sciences;Sabzevar University of Medical Sciences

关键词: Toxic effect;    Histopathological study;    Oxothiazole derivative;   

DOI  :  10.22067/veterinary.v2i10.71626

学科分类：医学（综合）

来源: Ferdowsi University of Mashhad

【 摘 要 】

The spread of antibiotic-resistant bacteria in many humans and animals has driven researches to identify and design novel antibacterial agents. In vitro inhibitory activity of (2E)-2-(4,5-dihydro-4-oxothiazol-2-yl)-2-(thiazolidin-2-ylidene) acetonitrile against many bacterial pathogens has been proven in both veterinary and human medicine. In this study, its in vivo toxic effects was studied in mice. The median lethal dose (LD50) value of 239.88 mg/kg was estimated using intraperitoneal injection in 8 groups of mice after 48 h treatment. Then, intraperitoneal injections of LD50 of oxothiazole solution into 4 other mice were done to evaluate histopathological changes in their liver and kidney tissues. The histopathological studies were identified as fatty change, hepatitis, necrosis and regeneration in liver, and fibrosis, necrosis, nephritis, hyaline cast and hyperaemia in kidney. In conclusion, the synthesized oxothiazole derivative causes renal and hepatic toxicity in mice at medium concentrations. The change of thiazole substituents and complexation may reduce its toxicity.

【 授权许可】

CC BY