South African Journal of Oncology | |
RETRACTION: High incidence of cisplatin-induced ototoxicity in paediatric patients in the Western Cape, South Africa | |
ARTICLE | |
Mukovhe Phanguphangu1  Lebogang Ramma1  | |
[1] Faculty of Health Sciences, University of Cape Town;Faculty of Health Sciences, University of Fort Hare | |
关键词: Cisplatin; ototoxicity; paediatrics; hearing loss; sensorineural; South Africa; | |
DOI : 10.4102/sajo.v2i0.41 | |
学科分类:工业工程学 | |
来源: AOSIS | |
【 摘 要 】
Background: Fourteen million new cancer cases are reported annually, and up to 10% of those involve children below 15 years. Cisplatin, a commonly used anti-cancer drug for its high success rate, is associated with ototoxicity. Cisplatin-induced ototoxicity is characterised by permanent bilateral severe-to-profound hearing loss. Hearing loss, when occurring during childhood, can impact negatively communication development, scholastic performance and quality of life. Aim: To determine the incidence of cisplatin-induced ototoxicity in paediatric oncology. Setting: A retrospective records review of paediatric oncology patients who underwent cisplatin-based chemotherapy and had ototoxicity monitoring from January 2015 to December 2017 at a children’s hospital. Method: Data collected included demographic, cisplatin treatment and audiometric information. The data were analysed using descriptive and inferential statistics. Results: A total of 49 records meeting the inclusion criteria were reviewed. Ototoxic hearing loss was found in 39 (80%) of the patients whose records were reviewed and the majority (56%) presented with a bilateral moderate-to-severe sensorineural hearing loss. Distortion product otoacoustic emissions were absent in 32 (67%) patients. Cumulative dose (> 200 mg/m2 ) was associated with higher incidences of ototoxicity (odds ratio [OR]: 1.81; 95% confidence interval [CI]: 0.67–17.34; p = 0.044). Younger patients (< 10 years) had higher odds of developing ototoxicity, but this was not statistically significant (OR: 4.00; 95% CI: 0.82–19.46; p = 0.085). Conclusion: This study found a high incidence of cisplatin-induced ototoxicity in paediatric oncology patients. This is concerning because hearing loss during this age can have long-term negative impact on a child’s development and overall quality of life. Early identification of ototoxicity-induced hearing loss and appropriate intervention are highly recommended in this patient group.
【 授权许可】
CC BY
【 预 览 】
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