Comparing the Antinociceptive Effects of Methamphetamine, Buprenorphine, or Both After Chronic Treatment and Withdrawal in Male Rats

Basic and Clinical Neuroscience

ARTICLE

Etaee, Farshid¹  Rezvani-Kamran, Arezoo¹  Taheri, Mohammad¹  Omidi, Ghazaleh¹  Hasanein, Parisa³  Komaki, Alireza¹ 

[1] Neurophysiology Research Center, Hamadan University of Medical Sciences;Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences;Department of Biology, School of Sciences, University of Zabol

关键词: Methamphetamine;    Buprenorphine;    Pain;    Hot plate;    Tail flick;    Interactions;   

DOI  :  10.32598/bcn.10.4.290.5

来源: Iran University of Medical Sciences

【 摘 要 】

Introduction:Methamphetamine (Meth) and Buprenorphine (BUP) modulate pain perception. However, the antinociceptive effects of their interactions, which affect through different systems, are unclear in rats. This study aimed to compare the analgesic effects of Meth, BUP, and their coadministration, as well as the effect of withdrawal from these substances on nociception in male rats. Methods: In this experiment, 40 male Wistar rats (weight: 250-300 g) were categorized into four groups: control, Meth, BUP, or BUP+Meth. After seven days of treatments, the antinociceptive effects were assessed using the hot plate and the tail flick tests. The differences among the groups were analyzed with ANOVA and Tukey’s post hoc tests. P values less than 0.05 were considered significant. Results: Meth and BUP increased the reaction times during the hot plate and tail flick tests. The combination of Meth and BUP increased reaction time more than Meth or BUP alone. Conclusion: The significantly high reaction times in rats treated with Meth and BUP indicate that these substances have antinociceptive effects. In addition, Meth enhanced the antinociceptive effects of BUP. These synergistic effects might occur through the dopaminergic, serotonergic, and or adrenergic systems.

【 授权许可】

Unknown