Clinical Characteristics of Kawasaki Disease in Markazi Province, Iran

Journal of Comprehensive Pediatrics

ARTICLE

Ghandi, Yazdan¹  Habibi, Danial²  Kahbazi , Manigeh³  Dorreh, Fatemeh⁴  Lotfi , Maryam³ 

[1] Department of Pediatric Cardiology, Arak University of Medical Sciences;Department of Biostatistics, Arak University of Medical Sciences;Department of Pediatric Infection, Amirkabir Hospital, School of Medicine, Arak University of Medical Sciences;Department of Pediatrics, School of Medicine, Arak University of Medical Sciences

关键词: Children;    Vasculitis;    Iran;    Kawasaki Disease;    Epidemiology;   

DOI  :  10.5812/compreped.85695

来源: Kowsarmedical

【 摘 要 】

Background: Kawasaki disease (KD) is described as a life-threatening vasculitis, which mostly develops in children below five years of age and is diagnosed according to clinical criteria. It is also a common rheumatologic disorder in Iran. Objectives: The present study aimed at determining the clinical and demographic characteristics of KD patients in Iran. Methods: We retrospectively assessed 69 cases of KD in an Iranian pediatric population from March 2014 to March 2018. The Japanese Kawasaki Disease Research Committee guidelines were used as the diagnostic criteria for typical KD. Incomplete or atypical KD was diagnosed in patients with coronary artery changes, but without all the criteria for KD. Results: In this study, 69 patients were recruited, with a male-female ratio of 1:8. Overall, 64% (n, 44) and 36% of children met the criteria for typical and atypical KD, respectively. Also, echocardiographic abnormalities were reported in eight patients (12%). Coronary artery aneurysm was found in 2% of patients, while other cardiac abnormalities were found in 12% of patients. The male-female ratio of coronary artery anomalies and other cardiac abnormalities was 3:1. Polymorphic exanthema was the most common clinical manifestation. The erythrocyte sedimentation rate ≥ 40 mm/h was the most common laboratory finding, while skin desquamation was the most common complication in other organs. Conclusions: KD is not uncommon in Markazi Province, Iran. In this study, distribution of demographic characteristics was not similar to reports from other countries. Also, clinical findings, age and gender distribution, laboratory findings, and complications in other organs were not similar to previous reports. The incidence of typical and atypical KD was different in this region, especially in terms of complications, such as cardiac and gastrointestinal complications.

【 授权许可】

Unknown