Use of Brain Natriuretic Peptide in Predicting Severity of Respiratory Distress Syndrome in Neonates

Journal of Comprehensive Pediatrics

ARTICLE

Kumar, Suresh¹ 

[1]Department of Pediatrics, Chaitanya Hospital

关键词: Newborn;    Respiratory Distress Syndrome;    Brain;    Natriuretic Peptide;   

DOI  :  10.17795/compreped-16317

来源: Kowsarmedical

【 摘 要 】

Respiratory distress syndrome (RDS) remains the most common problem in preterm neonates resulting in significant morbidity, mortality, and extra health care costs (1, 2). Early identification of preterm neonates susceptible to RDS is important since they may benefit from prophylactic surfactant administration and/or less vigorous ventilation (3, 4). In this regard, Shahramian et al. (5) conducted a case control study involving 65 preterm infants 7 as cases and 65 term infants as controls and demonstrated that serum brain natriuretic peptide (BNP) levels correlated with increased severity of RDS among cases. They suggested that BNP can be used as a prediction marker for RDS in preterm neonates. BNP is secreted by cardiac myocytes in response to pressure or volume overload, the associated pathological changes of RDS (6). This fact has been explored in preterm neonates in prediction of RDS in various studies. Rocha et al. (7) studied plasma N-terminal pro-BNP in 45 preterm neonates at 24 hours, day 7 and day 21 of life, and demonstrated that plasma BNP at 24 hours of life was directly related to increasing severity of RDS, suggesting a close relation to the functional impairment of pulmonary hemodynamic changes. Joseph et al. (8) studied plasma concentrations of N-terminal pro-BNP in 34 premature infants (without cardiac or infectious diseases) with a diagnosis of bronchopulmonary dysplasia (BPD) at 4 weeks of age and after 1 month of conventional therapy. They observed that baseline NT-pro-BNP concentrations were high in healthy premature infants compared with previously reported healthy neonates, and significantly higher in those who developed BPD. There was a significant correlation between concentrations of NT-pro-BNP and severity of respiratory distress.

【 授权许可】

Unknown