Interstitial Lung Disease in Anti-Synthetase Syndrome

Mediterranean Journal of Rheumatology

ARTICLE

Evangelia Kourkouni¹  Georgios Mitsogiannis¹  Theodora Simopoulou¹  Christos Liaskos¹  Christina G. Katsiari¹  Zoi Daniil²  Konstantinos Gourgoulianis²  Dimitrios P. Bogdanos¹  Lazaros I. Sakkas¹ 

[1] Department of Rheumatology and Clinical Immunology, University General Hospital of Larissa, Faculty of Medicine, University of Thessaly;Department of Respiratory Medicine, University General Hospital of Larissa, Faculty of Medicine, University of Thessaly

关键词: anti-synthetase syndrome;    anti-Jo1;    interstitial lung disease;    Raynaud’s phenomenon;   

DOI  :  10.31138/mjr.30.3.186

学科分类：社会科学、人文和艺术（综合）

来源: PCO Convin S.A.

【 摘 要 】

Anti-synthetase syndrome is an autoimmune disorder characterized by the presence of autoantibodies against aminoacyl transfer RNA (tRNA) synthetases, and myositis, interstitial lung disease (ILD), arthritis, fever and Raynaud’s phenomenon (RP). We present a 54-year-old woman, who complained of fatigue, low-grade fever, myalgias, arthralgias, RP and dyspnoea on exertion. Chest CT scan revealed features of interstitial lung disease. Due to rapid deterioration of her lung function, she required oxygen support. The patient did not respond to empiric treatment with antibiotics. Autoantibody testing was remarkable for ANA positivity (1/160) and high-titre anti-Jo1 positivity. A diagnosis of anti-synthetase syndrome was made and the patient was placed on high-dose corticosteroids and rituximab with significant improvement. At 1-year follow up, she remains in good condition, without the need for oxygen supplementation.

【 授权许可】

CC BY-NC