Anti-synthetase syndrome presenting with interstitial lung disease

Mediterranean Journal of Rheumatology

ARTICLE

Panagiotis Athanassiou¹  Markos Kostopoulos¹  Aikaterini Tzanavari¹  Anestis Spyridis¹  Ifigenia Kostoglou-Athanassiou² 

[1] Department of Rheumatology, St. Paul’s Hospital;Department of Endocrinology, Asclepeion Hospital

关键词: anti-synthetase syndrome;    mechanic’s hands;    interstitial lung disease;    myopathy;    azathioprine;   

DOI  :  10.31138/mjr.28.3.212

学科分类：社会科学、人文和艺术（综合）

来源: PCO Convin S.A.

【 摘 要 】

Anti-synthetase syndrome is an idiopathic inflammatory myopathy characterized by interstitial lung involvement, arthritis, Raynaud’s phenomenon, mechanic’s hands and fever. The case of antisynthetase syndrome in a young female is reported. The patient presented with interstitial lung disease, initially subclinical muscle involvement, Raynaud’s phenomenon, arthritis and mechanic’s hands. Induction therapy was administrated, that consisted of intravenous methylprednisolone and cyclophosphamide, followed by azathioprine and prednisone with good response, and finally, complete remission. The presence of mechanic’s hands in a patient with lung involvement should prompt for specific investigations such as anti-synthetase antibodies and muscle enzymes. Antisynthetase syndrome should be aggressively managed by immunosuppressive therapy, as interstitial lung disease is a severe manifestation of the disease which may affect quality of life and life expectancy.

【 授权许可】

CC BY-NC