Body-size phenotypes and cardiometabolic risk in Rheumatoid Arthritis (Short Title: Subgroups of obesity in RA)

Mediterranean Journal of Rheumatology

ARTICLE

Antonios Stavropoulos-Kalinoglou¹  George S. Metsios³  Yiannis Koutedakis¹  George D. Kitas³ 

[1] Department of Sport and Exercise Science, University of Thessaly;Institute of Human Performance & Rehabilitation, Centre for Research and Technology Thessaly;Department of Rheumatology, Dudley Group NHS Foundation Trust, Russell’s Hall Hospital;School of Sport, Wolverhampton University;Arthritis Research UK Epidemiology Unit, University of Manchester

关键词: body fat;    adiposity;    inflammation;    disease activity;    muscle mass;   

DOI  :  10.31138/mjr.27.2.48

学科分类：社会科学、人文和艺术（综合）

来源: PCO Convin S.A.

【 摘 要 】

Objectives: Obesity is a significant contributor to metabolic complications. However, such complications are not uniform in people with similar body-size. The existence of normal-weight individuals with and obese individuals without metabolic complications has been described in the general population and is important in the context of cardiovascular disease (CVD). This has not been investigated in rheumatoid arthritis (RA), a condition associated with increased cardiometabolic risk. This study aims to identify the prevalence and predictors of body-size phenotypes in RA and investigate their associations with CVD risk. Methods: Body mass index (BMI: kg/m2 ), body fat (BF) and fat free mass (FFM), RA characteristics and CVD risk factors were assessed in 363 (262 female) volunteers with RA. Abnormal cardiometabolic status was defined as the presence of >1 of the following: hypertension, increased triglycerides or increased Low or reduced High Density Lipoprotein, high glucose, insulin resistance. Results: Among normal-weight, overweight, and obese participants, 25%, 45.8%, 57.1% respectively were metabolically abnormal. Old age (B= 1.032, err=0.011; p= 0.005), waist circumference (B= 1.057, err= 0.011; p= 0.000), and smoking cessation (B= 1.425, err= 0.169; p=0.036) were significant predictors for metabolic abnormality. Conclusions: A significant number of RA patients present with different body-size and metabolic phenotypes. Body Mass Index alone is not a sufficient indicator of cardiometabolic risk in RA; this may have significant implications in their CVD risk evaluation. Body fat distribution seems to be a significant contributor to such abnormalities. Further research is needed, focusing on the metabolic properties of specific adipose depots of RA patients.

【 授权许可】

CC BY-NC