Risk Factors for Predicting Hypoxia in Adult Patients Undergoing Bronchoscopy under Sedation

Tuberculosis and Respiratory Diseases

article

Ji Soo Choi¹  Eun Hye Lee¹  Sang Hoon Lee²  Ah Young Leem²  Kyung Soo Chung²  Song Yee Kim²  Ji Ye Jung²  Young Ae Kang²  Moo Suk Park²  Joon Chang²  Young Sam Kim² 

[1] Division of Pulmonology, Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine;Division of Pulmonology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine

关键词: Bronchoscopy;    Hypoxia;    Risk Factors;   

DOI  :  10.4046/trd.2020.0002

学科分类：医学（综合）

来源: The Korean Academy of Tuberculosis and Respiratory Diseases

【 摘 要 】

Background Flexible bronchoscopy is one of the essential procedures for the diagnosis and treatment of pulmonary diseases. The purpose of this study was to identify the risk factors associated with the occurrence of hypoxia in adults undergoing flexible bronchoscopy under sedation. Methods We retrospectively analyzed 2,520 patients who underwent flexible bronchoscopy under sedation at our tertiary care university hospital in South Korea January 1, 2013-December 31, 2014. Hypoxia was defined as more than 5%-point reduction in the baseline percutaneous oxygen saturation (SpO 2 ) or SpO 2 1 minute during the procedure. Results The mean age was 64.7±13.5, and 565 patients developed hypoxia during the procedure. The mean sedation duration and midazolam dose for sedation were 31.1 minutes and 3.9 mg, respectively. The bivariate analysis showed that older age, a low forced expiratory volume in one second (FEV 1 ), use of endobronchial ultrasound, the duration of sedation, and the midazolam dose were associated with the occurrence of hypoxia during the procedure, while the multivariate analysis found that age >60 (odds ratio [OR], 1.32), a low FEV 1 (OR, 0.99), and a longer duration of sedation (>40 minutes; OR, 1.33) were significant risk factors. Conclusion The findings suggest that patients older than age 60 and those with a low FEV 1 tend to develop hypoxia during the bronchoscopy under sedation. Also, longer duration of sedation (>40 minutes) was a significant risk factor for hypoxia.

【 授权许可】

CC BY-NC