Development of Prediction Equation of Diffusing Capacity of Lung for Koreans

Tuberculosis and Respiratory Diseases

article

Yong Il Hwang¹  Yong Bum Park²  Hyoung Kyu Yoon³  Seong Yong Lim⁴  Tae-Hyung Kim⁵  Joo Hun Park⁶  Won-Yeon Lee⁷  Seong Ju Park⁸  Sei Won Lee⁹  Woo Jin Kim^1,10  Ki Uk Kim^1,11  Kyeong Cheol Shin^1,12  Do Jin Kim^1,13  Hui Jung Kim^1,14  Tae-Eun Kim^1,15  Kwang Ha Yoo^1,16  Jae Jeong Shim^1,17 

[1] Division of Pulmonary, Department of Internal Medicine, Hallym University Sacred Heart Hospital;Lung Research Institute of Hallym University College of Medicine;Division of Pulmonology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea;Division of Pulmonary and Critical Care Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine;Division of Pulmonology, Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine;Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Ajou University School of Medicine;Division of Pulmonary, Department of Internal Medicine, Yonsei University Wonju College of Medicine;Division of Pulmonary, Chonbuk National University Hospital, Chonbuk National University Medical School;Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine;Department of Internal Medicine, Kangwon National University School of Medicine;Department of Internal Medicine, Pusan National University School of Medicine;Regional Center for Respiratory Disease, Yeungnam University Medical Center, Yeungnam University College of Medicine;Division of Allergy and Respiratory Medicine, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital;Division of Pulmonary and Critical Care Medicine, Wonkwang University Sanbon Hospital, Wonkwang University School of Medicine;Department of Clinical Pharmacology, Konkuk University School of Medicine;Department of Internal Medicine, Konkuk University Medical Center;Division of Pulmonary, Department of Internal Medicine, Korea University Guro Hospital

关键词: Korean;    Pulmonary Diffusing Capacity;    Diffusion;    Carbon Monoxide;   

DOI  :  10.4046/trd.2017.0118

学科分类：医学（综合）

来源: The Korean Academy of Tuberculosis and Respiratory Diseases

【 摘 要 】

Background The diffusing capacity of the lung is influenced by multiple factors such as age, sex, height, weight, ethnicity and smoking status. Although a prediction equation for the diffusing capacity of Korea was proposed in the mid-1980s, this equation is not used currently. The aim of this study was to develop a new prediction equation for the diffusing capacity for Koreans. Methods Using the data of the Korean National Health and Nutrition Examination Survey, a total of 140 nonsmokers with normal chest X-rays were enrolled in this study. Results Using linear regression analysis, a new predicting equation for diffusing capacity was developed. For men, the following new equations were developed: carbon monoxide diffusing capacity (DLco)=−10.4433−0.1434×age (year)+0.2482×heights (cm); DLco/alveolar volume (VA)=6.01507−0.02374×age (year)−0.00233×heights (cm). For women the prediction equations were described as followed: DLco=−12.8895−0.0532×age (year)+0.2145×heights (cm) and DLco/VA=7.69516−0.02219×age (year)−0.01377×heights (cm). All equations were internally validated by k-fold cross validation method. Conclusion In this study, we developed new prediction equations for the diffusing capacity of the lungs of Koreans. A further study is needed to validate the new predicting equation for diffusing capacity.

【 授权许可】

CC BY-NC