Association of Specific Immunoglobulin E to Staphylococcal Enterotoxin with Airway Hyperresponsiveness in Asthma Patients

Tuberculosis and Respiratory Diseases

article

Seong Han Kim¹  Seo Yeon Yang¹  Jihong You¹  Sang Bae Lee¹  Jin You²  Yoon Soo Chang¹  Hyung Jung Kim¹  Chul Min Ahn¹  Min Kwang Byun¹  Hye Jung Park¹  Jung-Won Park³ 

[1] Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine;Department of Internal Medicine, Kunkuk University School of Medicine;Division of Allergy and Immunology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine

关键词: Immunoglobulin E;    Staphylococcus;    Enterotoxins;    Asthma;   

DOI  :  10.4046/trd.2016.79.4.295

学科分类：医学（综合）

来源: The Korean Academy of Tuberculosis and Respiratory Diseases

【 摘 要 】

Background Specific immunoglobulin E (IgE) sensitization to staphylococcal enterotoxin (SE) has been recently considered to be related to allergic disease, including asthma. Despite studies on specific IgE (sIgE) to SE and its relationship to asthma diagnosis and severity, the association of sIgE to SE with airway hyperresponsiveness (AHR) remains unclear. Methods We enrolled 81 asthma patients admitted to the Severance Hospital in Korea from March 1, 2013, to February 28, 2015 and retrospectively reviewed the electronic medical records of the enrolled subjects. The serum levels of sIgE to SE (A/B) of all subjects was measured using the ImmunoCAP 250 (Phadia) system with SE-sIgE positive defined as >0.10 kU/mL. Results The SE-sIgE level was not significantly correlated with asthma severity (forced expiratory volume in 1 second [FEV 1 ], FEV 1 /forced vital capacity, sputum eosinophils, and serum eosinophils), whereas the SE-sIgE level in patients with positive AHR (mean±standard error of the mean, 0.606±0.273 kU/mL) was significantly higher than that in patients with negative AHR (0.062±0.015 kU/mL, p=0.034). In regression analysis, SE sensitization (sIgE to SE ≥0.010 kU/mL) was a significant risk factor for AHR, after adjustment for age, sex, FEV 1 , and sputum eosinophils (odds ratio, 7.090; 95% confidence interval, 1.180-42.600; p=0.032). Prevalence of SE sensitization was higher in patients with allergic rhinitis and non-atopic asthma patients, as compared to patients without allergic rhinitis and atopic asthma patients, respectively, but without statistical significance. Conclusion SE sensitization is significantly associated with AHR.

【 授权许可】

CC BY-NC