Hipersensibilidad a corticoides y manejo en asma severa. A propósito de un caso

Revista Chilena de Enfermedades Respiratorias

Yáñez V., Jorge¹  Aguayo C., Miguel¹  Durán W., María Ignacia¹  Pinochet F., Víctor²  Azócar B., Claudia² 

[1] Hospital Clínico Regional de Concepción, Concepción, Chile;Universidad de Concepción, Concepción, Chile

关键词: Anaphylaxis;    Asthma;    Immunoglobulin E;    Adrenal cortex hormones;    Nebulizers;    vaporizers.;   

DOI  :  10.4067/s0717-73482018000100048

学科分类：社会科学、人文和艺术（综合）

来源: Sociedad Chilena de Enfermedades Respiratorias

【 摘 要 】

Hypersensitivity reactions to corticosteroids are rare in the general population, they fall into two categories: ‘immediate’, typically mediated by immunoglobulin E (IgE), which includes anaphylaxis after administration of a drug in a short period of time. Its reported prevalence is 0.3-0.5%. Another reaction is ‘not immediate’, which manifests itself in a time longer than one hour after the administration of the drug. We reviewed the literature with the aim of improving and clarifying the treatment in asthmatic patients with this condition. It was found that the possible routes to generate these reactions are intranasal, aerosol by inhaler, oral and parenteral. Facing this condition requires a close and detailed evaluation of the clinical history, symptoms and side reactions to the suspected drug. Finally, when choosing which corticosteroid to use, the patient's safety is paramount, and control of the disease is also essential.

【 授权许可】

CC BY