Changes in Diagnostic Methods for Pulmonary Tuberculosis between 2005 and 2013

Tuberculosis and Respiratory Diseases

article

Bin Ahn¹  Joohae Kim¹  Chul-Gyu Yoo¹  Young Whan Kim¹  Sung Koo Han¹  Jae-Joon Yim¹ 

[1] Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine

关键词: Tuberculosis;    Pulmonary;    Diagnosis;    Bronchoscopy;    Nucleic Acid Amplification Techniques;   

DOI  :  10.4046/trd.2015.78.3.227

学科分类：医学（综合）

来源: The Korean Academy of Tuberculosis and Respiratory Diseases

【 摘 要 】

Background Diagnostic methods for pulmonary tuberculosis (TB) have recently advanced. The aim of this study was to evaluate the changes in TB diagnostic tests that prompted the initiation of anti-TB treatment over time in South Korea, an industrialized country with an intermediate TB burden. Methods Patients diagnosed with pulmonary TB in the first halves of 2005 and 2013 at a tertiary referral hospital were included. Diagnostic methods that prompted the initiation of anti-TB treatment were compared between the 2 groups of patients. Results A greater proportion of patients were diagnosed with pulmonary TB using bronchoscopy in 2013 than in 2005 (26.7% vs. 6.6%, respectively; p<0.001), while the proportion of patients clinically diagnosed with pulmonary TB was lower in 2013 than in 2005 (24.7% vs. 49.0%, respectively; p<0.001). Additionally, more patients started anti-TB treatment based on positive polymerase chain reaction (PCR) results for Mycobacterium tuberculosis DNA in 2013 than in 2005 (47.3% vs. 7.9%, respectively; p<0.001). Conclusion The initiation of treatment for pulmonary TB in South Korea has become more frequently based on PCR and the use of bronchoscopic specimens.

【 授权许可】

CC BY-NC