p53 Expression in a Malignant Mesothelioma Patient during Seven-Year Follow-up

Tuberculosis and Respiratory Diseases

article

So-My Koo¹  Soo-taek Uh¹  Dong Won Kim²  Ki-Up Kim¹  Yang-Ki Kim¹ 

[1] Division of Allergy and Respiratory Medicine, Department of Internal Medicine, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine;Department of Pathology, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine

关键词: Mesothelioma;    Tumor Suppressor Protein p53;    Pleura;   

DOI  :  10.4046/trd.2014.76.6.284

学科分类：医学（综合）

来源: The Korean Academy of Tuberculosis and Respiratory Diseases

【 摘 要 】

Malignant mesothelioma (MM) is the aggressive tumor of serosal surfaces. There are crude pathogenetic results regarding the biology of MM. Coordinated upregulations of p53 gene expression are shown in malignancies. We believed that there are changes in the p53 expression with transformation from reactive hyperplasia to MM. A 65-year-old male was admitted the hospital because of left pleuritic chest pains in 2004. Chest computed tomography (CT) results showed left pleural effusions with loculation and pleural thickening. Pathologic findings revealed reactive mesothelial hyperplasia. In 2008, the patient again felt left pleuritic chest pains. Chest CT showed progressive thickening of the left pleura. Pathologic diagnosis was atypical mesothelial hyperplasia. In 2011, chest CT showed progressive thickening of his left pleura. He was diagnosed with well-differentiated papillary mesothelioma. Serial change was analyzed by immunohistochemical staining for p53 of pleural tissues. There were no remarkable changes in p53 expressions during the transformation to MM.

【 授权许可】

CC BY-NC