期刊论文详细信息
Tuberculosis and Respiratory Diseases
p53 Expression in a Malignant Mesothelioma Patient during Seven-Year Follow-up
article
So-My Koo1  Soo-taek Uh1  Dong Won Kim2  Ki-Up Kim1  Yang-Ki Kim1 
[1] Division of Allergy and Respiratory Medicine, Department of Internal Medicine, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine;Department of Pathology, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine
关键词: Mesothelioma;    Tumor Suppressor Protein p53;    Pleura;   
DOI  :  10.4046/trd.2014.76.6.284
学科分类:医学(综合)
来源: The Korean Academy of Tuberculosis and Respiratory Diseases
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【 摘 要 】

Malignant mesothelioma (MM) is the aggressive tumor of serosal surfaces. There are crude pathogenetic results regarding the biology of MM. Coordinated upregulations of p53 gene expression are shown in malignancies. We believed that there are changes in the p53 expression with transformation from reactive hyperplasia to MM. A 65-year-old male was admitted the hospital because of left pleuritic chest pains in 2004. Chest computed tomography (CT) results showed left pleural effusions with loculation and pleural thickening. Pathologic findings revealed reactive mesothelial hyperplasia. In 2008, the patient again felt left pleuritic chest pains. Chest CT showed progressive thickening of the left pleura. Pathologic diagnosis was atypical mesothelial hyperplasia. In 2011, chest CT showed progressive thickening of his left pleura. He was diagnosed with well-differentiated papillary mesothelioma. Serial change was analyzed by immunohistochemical staining for p53 of pleural tissues. There were no remarkable changes in p53 expressions during the transformation to MM.

【 授权许可】

CC BY-NC   

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