The First Korean Case of Nontuberculous Mycobacterial Lung Disease Caused by Mycobacterium abscessus Subspecies bolletii in a Patient with Bronchiectasis

Tuberculosis and Respiratory Diseases

article

Byeong-Ho Jeong¹  Su-Young Kim¹  Kyeongman Jeon¹  Hee Jae Huh²  Chang-Seok Ki²  Nam Yong Lee²  Sung Jae Shin³  Won-Jung Koh¹ 

[1] Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine;Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine;Department of Microbiology, Yonsei University College of Medicine

关键词: Bronchiectasis;    Mycobacterium Infections;    Nontuberculous;    Nontuberculous Mycobacteria;    Sequence Analysis;    DNA;   

DOI  :  10.4046/trd.2014.76.1.30

学科分类：医学（综合）

来源: The Korean Academy of Tuberculosis and Respiratory Diseases

【 摘 要 】

We report the first Korean case of lung diseases caused by Mycobacterium abscessus subsp. bolletii in a previously healthy male, except for a previous history of pulmonary tuberculosis and bronchiectasis. All serial isolates are identified as M. abscessus subsp. bolletii by multi-locus sequence analysis based on the hsp65 , rpoB , and 16S rRNA fragments. At the genetic level, the isolate has the erm (41) gene with a T28 sequevar, associated with clarithromycin resistance, and no rrl mutation. The isolate is resistant to clarithromycin. Although the symptoms and radiographic findings have improved after combination of antibiotics, the follow-up sputum cultures are persistently positive.

【 授权许可】

CC BY-NC