Mycobacterium abscessus Lung Disease in a Patient with Kartagener Syndrome

Tuberculosis and Respiratory Diseases

article

Jung Hoon Kim¹  Won Jun Song¹  Ji Eun Jun¹  Duck Hyun Ryu¹  Ji Eun Lee¹  Ho Jung Jeong¹  Suk Hyeon Jeong¹  Hyung Koo Kang¹  Jung Soo Kim¹  Hyun Lee¹  Hae Ri Chon¹  Kyeongman Jeon¹  Dohun Kim²  Jhingook Kim²  Won-Jung Koh¹ 

[1] Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine;Department of Thoracic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine

关键词: Kartagener Syndrome;    Primary Ciliary Dyskinesia;    Bronchiectasis;    Nontuberculous Mycobacteria;    Mycobacterium Infections;    Nontuberculous;   

DOI  :  10.4046/trd.2014.77.3.136

学科分类：医学（综合）

来源: The Korean Academy of Tuberculosis and Respiratory Diseases

【 摘 要 】

Primary ciliary dyskinesia (PCD) is characterized by the congenital impairment of mucociliary clearance. When accompanied by situs inversus, chronic sinusitis and bronchiectasis, PCD is known as Kartagener syndrome. The main consequence of impaired ciliary function is a reduced mucus clearance from the lungs, and susceptibility to chronic respiratory infections due to opportunistic pathogens, including nontuberculous mycobacteria (NTM). There has been no report of NTM lung disease combined with Kartagener syndrome in Korea. Here, we report an adult patient with Kartagener syndrome complicated with Mycobacterium abscessus lung disease. A 37-year-old female presented to our hospital with chronic cough and sputum. She was ultimately diagnosed with M. abscessus lung disease and Kartagener syndrome. M. abscessus was repeatedly isolated from sputum specimens collected from the patient, despite prolonged antibiotic treatment. The patient's condition improved and negative sputum culture conversion was achieved after sequential bilateral pulmonary resection.

【 授权许可】

CC BY-NC