Mycobacterium intracellulare Pulmonary Disease with Endobronchial Caseation in a Patient Treated with Methotrexate

Tuberculosis and Respiratory Diseases

article

Jin Sun Park¹  Eul Sik Jung¹  Woosuk Choi¹  Soo Yong Park¹  Min Young Rim¹  Inku Yu¹  Hyeonsu Park¹  Sang Min Lee¹  Jeong-Woong Park¹  Sung Hwan Jeong¹  Sang Pyo Lee¹  Sanghui Park² 

[1] Department of Internal Medicine, Gachon University Gil Hospital, Gachon University Medicine and Science, Incheon;Department of Pathology, Ewha Womans University School of Medicine

关键词: Nontuberculous Mycobacteria;    Tuberculosis;    Pulmonary;    Methotrexate;    Arthiritis;    Rheumatoid;    Bronchial Diseases;   

DOI  :  10.4046/trd.2013.75.1.28

学科分类：医学（综合）

来源: The Korean Academy of Tuberculosis and Respiratory Diseases

【 摘 要 】

Methotrexate (MTX) has been established as a standard disease-modifying anti-rheumatic drug. If adequate disease control is achieved for a reasonable period of time, tapering the MTX dosage is recommended because the chronic use of MTX can result in opportunistic infection. We present here a case of a woman with rheumatoid arthritis taking MTX, and the woman developed actively caseating endobronchial Mycobacterium intracellulare disease with pulmonary infiltrations. After discontinuing the MTX, the patient was able to tolerate 18 months of antimycobacterial treatment without flare ups of rheumatoid arthritis, and she completely recovered from nontuberculous mycobacterial respiratory disease.

【 授权许可】

CC BY-NC